Effects of aqueous extract of Basella alba leaves on haematological and biochemical parameters in albino rats. This study was designed to investigate the hypocholesterolemic and antiatherosclerotic effects of Basella alba (B. alba) using hypercholesterolemia-induced rabbits. 2. Growth inhibition and apoptosis of Ehrlich ascites carcinoma cells by the methanol extract of Eucalyptus camaldulensis. After filtration, the residue obtained was again resuspended in equal volume of 95% ethanol for 48h and filtered again. Further investigations are needed on the mechanisms of B. alba in inhibiting the atherosclerotic plaque formation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Significant differences of values are compared to values of control and treated samples and marked as (. Blood samples were collected at 0, 4, 8, and 12th week via ear marginal vein using 23-gauge butterfly needle and 3 mL syringes into EDTA and heparinised tubes. B. alba leaf extract could be an effective alternative treatment for hypercholesterolemia and atherosclerosis. B. alba successfully inhibited the atherosclerotic plaque formation in hypercholesterolemia-induced model. Les feuilles charnues sont comestibles et constituent un substitut de l'épinard. Treatment with B. alba extract also significantly suppressed the aortic plaque formation and reduced the intima: media ratio as observed in simvastatin-treated group. AIM: To find an in vitro system for the measurement of the androgenic effects of different extracts of Hibiscus macranthus (Malvaceae) and Basella alba (Basellaceae). A dark semi solid material (7.23 %) … 2016 Jul 12;16:211. doi: 10.1186/s12906-016-1185-y. Basella alba (B. alba) extract showed the highest enzyme inhibition, about 74% [5]. ASSAMESE : Boga puroi, পূৰৈ Puroi, পূৰৈ শাক Puroi sak. One-way analysis of variance (ANOVA) followed by Dunnett’s post hoc test for multiple comparisons among the groups was performed. Basella Alba is considered safe for consumption. Characterization and evaluation of antibacterial and antiproliferative activities of crude protein extracts isolated from the seed of Ricinus communis in Bangladesh. Basella cananifolia Buch.-Ham. It is effective for Diuresis. It is found in tropical Asia and Africa where it is widely used as a leaf vegetable. Sexual Benefits Researchers in one study concluded that the traditional use of Basella in the treatment of male infertility and sexual asthenia helps balance out androgens and estrogens in the male body, thus boosting libido. Meanwhile, simvastatin-treated groups showed significant reduction () in SOD and GPx, 4 and 19%, respectively. G1: normal control, G2: hypercholesterolemic control, G3: simvastatin-treated (10 mg/kg), G4: T. Yokozawa, E. J. Cho, S. Sasaki, A. Satoh, T. Okamoto, and Y. Sei, “The protective role of Chinese prescription Kangen-karyu extract on diet-induced hypercholesterolemia in rats,”, S. K. Yeap, B. K. Beh, W. Y. Ho et al., “In vivo antioxidant and hypolipidemic effects of fermented mung bean on hypercholesterolemic mice,”, S. Salvamani, B. Gunasekaran, N. A. Shaharuddin, S. A. Ahmad, and M. Y. Shukor, “Antiartherosclerotic effects of plant flavonoids,”, M. F. Ismail, M. Z. Gad, and M. A. Hamdy, “Study of the hypolipidemic properties of pectin, garlic and ginseng in hypercholesterolemic rabbits,”, G. Baskaran, S. Salvamani, S. A. Ahmad, N. A. Shaharuddin, P. D. Pattiram, and M. Y. Shukor, “HMG-CoA reductase inhibitory activity and phytocomponent investigation of, R. Adhikari, K. H. Naveen, and S. Shruthi, “A review on medicinal importance of, H. Yasmin, M. A. Kaisar, M. M. R. Sarker, M. S. Rahman, and M. A. Rashid, “Preliminary anti-bacterial activity of some indigenous plants of Bangladesh,”, P. Balachandran and R. Govindarajan, “Cancer—an ayurvedic perspective,”, A. From the results obtained, it can be concluded that B. alba possesses therapeutic effects in treating hypercholesterolemia and atherosclerosis. Other common names include Vine Spinach, Red Vine Spinach, Creeping Spinach, and Ceylon Spinach. The serum levels of ALT, AST, and creatine kinase (CK) were evaluated by enzymatic kit (Randox Laboratories, Crumlin, UK) using Hitachi chemistry analyzer (Tokyo, Japan). The diets were vacuum-packed and stored in −20°C freezer. B. alba is known as Indian spinach and Remayung locally and belongs to the family of Basellaceae. The difference between groups was considered to be statistically significant when . When the scavenging receptor for oxidized LDL on macrophages is upregulated, it leads to foam cells formation which are the major component of fatty streaks. 133–139. A study investigated the effect of ethanolic extract of Basella alba on lead-induced hepatotoxicity in male rats which showed that the levels of alkaline phosphate, aspartate aminotransferase and alanine aminotransferase were significantly reduced while glutathione was significantly increased in Basella alba treated groups compared to lead control group at (p < 0.05). B. alba at dose of 200 mg/kg has significantly higher hypocholesterolemic effect than that of 100 mg/kg. The absorbance of the mixture was determined at 505 nm. Representative photographs of rabbits’ aortic arch from 5 groups stained with H&E. [21]; this could be due to the reduced antioxidant capacity in the serum of the animal model. The traditional medicinal plant Basella alba belongs to Basellaceae. B. alba leaf and seed extract exhibit a considerable scavenging activity in comparison to a standard antioxidant BHT. Levels of total cholesterol, LDL, triglycerides, and HDL in serum of rabbits from various groups. M.R.Almeida Basella alba var. The finding from in vivo study is in good agreement with that of in vitro study with HMG CoA reductase, confirming the cholesterol lowering effect of B. alba. 2014;7(1):S442–S447. Basella alba is an edible perennial vine in the family Basellaceae. All groups were analyzed using SPSS program version 19.0. A., Oparaji C. K and Ezeigbo N. Effects of aqueous extract of Basella alba leaves on haematological and biochemical parameters in albino rats. Find the perfect basella alba stock photo. Leaves are high in vitamin A, vitamin c, iron and calcium. Malabar spinach (Basella alba or Basella rubra) is not a true spinach, but rather a climbing vine in a class by itself. Clipboard, Search History, and several other advanced features are temporarily unavailable. The aortic arch of the rabbits was removed, cleaned, dried, and fixed in 10% neutral buffer formalin. The high cholesterol diet was prepared by dissolving 2% cholesterol (USP grade, anhydrous; Sigma Chemical Co., Missouri, USA) in 99% chloroform and sprayed on standard pellets. Screening of Indian medicinal plants for acetylcholinesterase inhibitory activity. Thickness of intima, media, and intima/media ratio of experimental rabbits at week 12. 600 mg, 400 mg and 200 mg of methanolic and aqueous extracts of Basella alba and Nepeta cataria were weighed and stored in well … There were significant decreases () in the level of TC, LDL, and TG at week 12, after 4 weeks of treatment with simvastatin and B. alba extract. -, Aruoma O. I. The rabbits were placed individually in stainless steel cages and were fed standard rabbit pellets for 1 week for acclimatization. Appearance ： Brown fine powder. Morphological alteration under fluorescence microscope showed nuclear condensation and fragmentation which is the sign of apoptosis. Hypercholesterolemia is characterized by increased serum concentrations of low-density lipoprotein (LDL) and triglycerides (TG) [1]. Hence, the scientists are trying to seek for noble compounds from natural sources to treat cancer. NIH The histopathological examination of aorta correlates with the serum biochemical data. Basella alba is a succulent, branched, twining herbaceous, perennial plant which is cultivated as a vegetable.This plant is also known as Malabar spinach, Indian spinach, Ceylon spinach, East-Indian spinach, Vine spinach, Climbing spinach, Chinese spinach, Cyclone spinach and Alugbati.. Malabar spinach is an edible flowering plant in family Basellaceae native to tropical Southern Asia which was … International Journal of Phytopharmacology. African Journal of Biotechnology. Indeed, plant polyphenols have been reported to regulate antioxidative status by ameliorating the activity of antioxidant enzymes [20]. Basella Alba is an edible perennial vine, which grows leaves that look like spinach. doi: 10.1016/S1995-7645(14)60272-8. Publication Author Huxley. Basella alba L. (Hooghly): This is from our kitchen garden, Basella alba L. or PUIN (পুঁই) in Bengali, a much liked vegetable (SHAK/SHAG) in our lunch dish. Normal control group (G1) showed healthy aorta with uniform thickness and intact endothelial lining. This study was designed to investigate the hypocholesterolemic and antiatherosclerotic effects of Basella alba ( B. alba ) using … BENGALI : Puin saag, পুঁই শাক Pui shaak. Malabar spinach, Basella alba, is a popular green leafy vegetable in other parts of the world. It is commonly grown as backyard plant or in the home garden. We are committed to sharing findings related to COVID-19 as quickly as possible. In this study, we examined the effect of B. alba leaves on the growth of Spodoptera litura larvae. 2015;6(4):246–254. On the other hand, significant reductions () were noted in the thickness of intima and media as well as intima/media ratio of simvastatin and B. alba (100 and 200 mg/kg) treated groups compared to the hypercholesterolemic control group. and it involves a complex array of enzyme activation, migration, tissue breakdown and repair -3354 on: 17 -03 2012 Revised on: 17-04-2012 Accepted on: 23-04-2012 DOI: 10.7324/JAPS.2012.2413 granuloma method. Toxicol Res. Basella alba leaf extract showed the highest inhibitory effect at about 74%. BURMESE : Ginbeik, King-peim.ni. Under both fluorescence microscope and optical microscope, normal and round shape nucleuses as well as cells appeared where cells from leaf and seed treated mice showed the nucleuses and cells having apoptotic properties that are indicated by white arrows. A. In this study, 25 medicinal plant methanol extracts were screened for anti-HMG-CoA reductase activity. Fluorescence and optical microscopic observation of EAC cells for control mice and treated mice. Significant increase in HDL as shown in B. alba-treated rabbits is a desirable criterion for an ideal hypercholesterolemic agent since it reduces the atherosclerotic risk. Its leaves and stem are cooked and used to treat Constipation. [9]. The marker enzymes, ALT and AST, were evaluated to detect the liver damage while CK was used to diagnose the muscle injury. The authors declare that there is no conflict of interests regarding the publication of this paper. cordifolia (Lam.) There are no known side effects linked to this vine/vegetable. It is well known that the hypocholesterolemic drugs are effective in lowering LDL but the long term consumption causes adverse effects such as liver and muscle injuries, rhabdomyolysis, myopathy, and acute renal failure. Levels of antioxidant enzymes in serum of rabbits from various groups. Pharm Biol. Effects of B. alba on fasting blood glucose in stressed rats The FBG of group 4 (85.2 ± 1.49 mg/dL) and group 5 (72.8 ± 1.36 mg/dL) rats given 60 mg/kg of B. alba extract at the end of the second week were significantly higher than normal control (54.4 ± 1.86 mg/dL) but significantly lower than stress control (groups 2) (106.2 ± 4.55 mg/dL) and group 3 (114.86 ± 6.12 mg/dL). B. alba leaf was washed thoroughly and air-dried at room temperature for overnight. Treatment with simvastatin and B. alba (100 and 200 mg/kg) showed significant increase () in HDL levels, 31.7, 39.6, and 53.4%, respectively. Therefore, this suggests that B. alba extract is capable of improving the antioxidant status and could be beneficial in managing oxidative damage and preventing lipid peroxidation. 4.4 leaf area. Health benefits of Nderema(basella alba) Basella also known as vine spinach is a popular tropical leafy green vegetable. On the other hand, hypercholesterolemic control group (G2) caused alteration in the aortic wall with the appearance of a large atheromatous plaque and demonstrated a remarkable intimal thickening of aorta. As shown in Table 4, the hypercholesterolemic control showed significant reduction () in the levels of SOD and GPx throughout the study. Basella alba is a green leafy vegetable used as medicinal plant in folk medicine for treatment of male reproductive dysfunctions in West Region of Cameroon.1 Previous scientific studies showed that the active principles of B. alba were concentrated in the methanol fraction.2,3 Indeed, the stimulatory effect of Data expressed as mean ± SD (n = 3) for all tested dosages. Administration with 10 mg/kg of simvastatin, used as a positive control, significantly decreased 58.9, 51.1, and 40.9% in TC, LDL, and TG levels, respectively. Therefore, the present study was aimed at investigating the hypocholesterolemic and antiatherosclerotic properties of B. alba in hypercholesterolemic rabbits and also at determining the antioxidant capacity of this extract. Administration of B. alba at 100 and 200 mg/kg decreased TC level by 49 and 54.2%, respectively, LDL level by 45 and 50.1%, respectively, and TG level by 34.9 and 39.7%, respectively. In that case the earlier treatments (B. rubra, B. alba var. Effects of the Methanol Extract of Basella alba L (Basellaceae) on Steroid Production in Leydig Cells Edouard Akono Nantia 1, Carine Travert 2, Faustin-Pascal T. Manfo 1, Serge Carreau 2, Thomas K. Monsees 3 and Paul Fewou Moundipa 1,* 1 Laboratory of Pharmacology and Toxicology, Department of Biochemistry, University of Yaoundé I, PO. Phytotherapy Research. Due to the side effects of statins, natural HMG-CoA reductase inhibitors of plant origin are needed. The data obtained are expressed as mean ± SD. Leaf extracts showed…, Cytotoxic activity of leaf and seed extract of B. alba . Akin to spinach, regular consumption of basella (Malabar spinach) in the diet helps prevent osteoporosis (weakness of bones), iron-deficiency anemia. Unless you are specifically allergic to Basella Alba, you should not experience side effects when eating this plant or consuming it in dietary supplements. 5. Basella alba has been used for many of its useful product from ancient times. Basella alba, la baselle ou épinard de Malabar, est une espèce de plantes dicotylédones de la famille des Basellaceae, probablement originaire d'Asie du Sud. HCD feeding showed significant elevation of TC, LDL, and TG, which increase lipid peroxidation and influence the development of atherosclerosis, in agreement with several studies [12]. The rabbits administered simvastatin or B. alba extract had reduction in body weight and serum levels of TC, LDL, and TG and significant increase noted in HDL levels. These enzymes were reported to leak into the blood circulation when their cell membranes were injured [17]. Butylated hydroxyanisole (0.02% of diet) was dissolved in chloroform to reduce oxidation of cholesterol. 2014 Mar;52(3):281-90. doi: 10.3109/13880209.2013.834365. Pre-Clinical Data. The hypercholesterolemia-induced rabbits showed significant increase () in ALT, AST, and CK levels as presented in Table 3. | Will Basella Alba Increase Testosterone Levels? This tender perennial native to tropical Asia, likely India and Sri Lanka or Indonesia (hardy only to zone 10), is easily grown as an annual during the heat of summer. It was tested for ant inflammatory activity in albino rats. Basella cordifolia Lam. There are no in vivo reports on the effects of B. alba on hypercholesterolemia up to date. This suggests high concentration of cholesterol and the usage of simvastatin caused liver and muscle damage [18, 19], whereas administration of B. alba extract for 4 weeks reduced the elevations of ALT, AST, and CK indicating its hepatic and muscle-protective effects. Isolation and identification of bioactive compounds of B. alba that are responsible for the observed effects are needed, which can be developed as a prophylactic agent against hypercholesterolemia and atherosclerosis. This contributes to atheromatous plaque formation and thickening of intimal layer [28, 29]. 1 1 Nutrient management and effects of netting on growth and yield 2 of Indian spinach (Basella alba) 3 M. Mishu Akther1, M. Ashraful Islam 1*, M. Saidee Rahman1, M. Rezaul Karim 1, 4 Dilip Nandwani2 5 1Department of Horticulture, Bangladesh Agricultural University, Mymensingh 2202, 6 Bangladesh; mishu.bau4@gmail.com (M.M.A); ashrafulmi@bau.edu.bd (M.A.I. It is listed as a potential environmental weed in Australia and as a weed of sugarcane fields on Iriomote Island, Japan. This species in the family Basellaceae (unrelated to true spinach in the Chenopodiaceae) sometimes goes by other common names including … The elevated levels of liver enzymes (AST and ALT) and creatine kinase were noted in hypercholesterolemic and statin treated groups indicating liver and muscle injuries. As shown in Table 2, serum levels of TC, LDL, and TG were significantly higher () in rabbits fed with HCD compared to the normal diet group after 8 weeks. Upregulation of the tumor suppressor gene P53 and downregulation of antiapoptotic gene Bcl-2 enumerate apoptosis induction. It is used as a leaf vegetable, and you may have heard of it referred to as a 'creeping spinach' or 'vine spinach'. 2010;9:6952–6955. 2020 Aug;44(8):e13342. Al-Mamun MA, Akter Z, Uddin MJ, Ferdaus KM, Hoque KM, Ferdousi Z, Reza MA. Gas chromatography with tandem mass spectrometry … Nowadays, alternative treatment using medicinal plants gained much attention since the usage of statins leads to adverse health effects, especially liver and muscle toxicity. B. alba extract (200 mg/kg) reduces TC, LDL, and TG levels as effectively as simvastatin. There are no other known side effects. The current treatment options of cancer are radiotherapy, chemotherapy, hormone therapy, and surgery, where all of them have unpleasant side effects. Hypercholesterolemia is the major risk factor that leads to atherosclerosis. The accumulation of oxidized LDL in macrophages can stimulate proliferation of monocytes, smooth muscle cells, and endothelial cells. It is a succulent, branched, smooth, twining herbaceous vine, several meters in length. Basella alba L. is claimed to be used as an antidote for poisons but has not been scientific adequately explored. Epidemiological and clinical studies have shown that low level of HDL plays a crucial role in the atherogenic process [15]; thus, therapeutic approach to increase the HDL level is widely encouraged [16]. A. Adaramoye, V. O. Nwaneri, K. C. Anyanwo, E. O. Farombi, and G. O. Emerole, “Possible anti-atherogenic effect of kolaviron (a, J.-R. Nofer, B. Kehrel, M. Fobker, B. Levkau, G. Assmann, and A. V. Eckardstein, “HDL and arteriosclerosis: beyond reverse cholesterol transport,”, G. Assmann and A. M. Gotto Jr., “HDL cholesterol and protective factors in atherosclerosis,”, O. Pharmacology Androgenic activity. A significant decrease in GPx activity in simvastatin-treated group was also noted by Trocha et al. Basella japonica Burm.fil. It is usually found in tropical parts of the world including Asia and Africa. Basella alba is a wildly cultivated, cool season vegetable with climbing growth habit. The mechanism by which B. alba inhibits the atherosclerotic plaque is not known but may be due to its antioxidant, hypocholesterolemic, and antiatherosclerotic effects such as decreasing oxidative stress, lowering the LDL level, reducing inflammation, and inhibiting macrophage accumulation. B. alba leaf was purchased from a local market in Seri Kembangan, Selangor, Malaysia. The in vivo study was carried out for 12 weeks. In previous study, we have screened the HMG CoA reductase inhibitory activity of 25 medicinal plants extracts. Basella cananifolia Buch.-Ham. It is listed as a potential environmental weed in Australia and as a weed of sugarcane fields on Iriomote Island, Japan. Thus, B. alba was examined in order to investigate its phytochemical components. Cancer is a class of diseases characterized by uncontrolled cell growth. This ingredient is … It is used against snake bites, insect bites, etc. Medicinal and … doi: 10.1002/ptr.2224. Basella alba is a perennial plant of the Basellaceae and is known by various common names including Malabar spinach. Fruit Trees > Perennial vegetables > Malabar Spinach - Red. Title The New RHS Dictionary of Gardening. Basella crassifolia Salisb. doi: 10.1111/jfbc.13342. Epub 2013 Oct 9. 2016 May 31;16:157. doi: 10.1186/s12906-016-1130-0. Its flowers possess the attributes of an Antidote. Effects of Growing Environments on the microflora of Basella alba and Basella rubra. In haemocytometic observation, the leaf and seed extracts exhibit about 62.54±2.41% and 53.96±2.34% cell growth inhibition, respectively, whereas standard anticancer drug Bleomycin showed 79.43±1.92% growth inhibition. In our present study, feeding hypercholesterolemic diet for 8 weeks leads to the reduction in the activities of SOD and GPx. subcordata Hassk. The fresh overnight cultures were diluted into the sterile normal saline equivalent to 0.5 MacFarland standard to prepare the test organism and inoculated on Mueller Hinton agar plates to determine the antibacterial activity of Basella alba and Nepeta cataria extract. The leaf was grounded using a blender (MX 8967, Panasonic) and subjected to methanol 50% (v/v) distillation for 48 hours. Accumulation of oxidized LDL leads to atherosclerotic plaque formation which contributes to stroke, myocardial infarction, and cardiovascular diseases (CVDs) [2]. | Food and water consumption were recorded daily, while the body weight was measured every 2 weeks. A. Adaramoye, O. Akintayo, J. Achem, and M. A. Fafunso, “Lipid-lowering effects of methanolic extract of, F. Martinello, S. M. Soares, J. J. Franco et al., “Hypolipemic and antioxidant activities from, S. Bolkent, R. Yanardag, S. Bolkent, and M. M. Döger, “Beneficial effects of combined treatment with niacin and chromium on the liver of hyperlipemic rats,”, R. S. Scott, C. J. Lintott, and M. J. Wilson, “Simvastatin and side effects,”, M. I. Kazeem, M. A. Akanji, M. T. Yakubu, and A. O. T. Ashafa, “Protective effect of free and bound polyphenol extracts from ginger (, M. Trocha, A. Merwid-Lad, E. Chlebda, M. Pieśniewska, T. Sozański, and A. Szelag, “Effect of simvastatin treatment on rat livers subjected to ischemia/reperfusion,”, K. Prasad and J. Kalra, “Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E,”, M. A. Mikail, I. Cyunel E. Basella alba L. In vitro culture and the production of betalains. Serum total cholesterol (TC), LDL, HDL, and triglycerides (TG) levels were determined using Roche kit (Penzberg, Germany) and measured spectrophotometrically using Hitachi chemistry analyzer (Tokyo, Japan). Biotechnology in agriculture and forestry. Cell growth inhibition was determined by haemocytometer whereas apoptosis of cancer cells were studied by florescence microscope using Hoechst-33342 stain and result was supported by DNA fragmentation and certain cancer related genes expression through PCR analysis. Besides, it is believed to protect the body from cardiovascular diseases and cancers of the colon. 4.3 vine length. Growth is slow in low temperatures resulting in low yields. Huge collection, amazing choice, 100+ million high quality, affordable RF and RM images. Baselle : La baselle, Basella alba synonyme de Basella rubra, famille des Basellacées. The potential of medicinal plants that exhibit hypocholesterolemic and antiartherosclerotic effects is still largely unexplored and could be an effective and safe alternative strategy for the treatment of hypercholesterolemia. Throughout the study, all the rabbits were kept in a 12 h light-dark cycle room with almost constant temperature at 23–25°C. Rahi MS, Islam MS, Jerin I, Jahangir CA, Hasan MM, Hoque KMF, Reza MA. With low calorie and high nutrients, it is a healthy food that you prefer. This tender perennial native to tropical Asia, likely India and Sri Lanka or Indonesia (hardy only to zone 10), is easily grown as an annual during the heat of summer. Antioxidant enzymes (SOD and GPx) play essential roles in maintaining the physiological concentrations of oxygen and hydrogen peroxide by improving the dismutation of oxygen radicals [20]. The chloroform was evaporated by exposing the diets in well-ventilated fume hoods at room temperature for overnight. They often contain a range of “natural” ingredients, which may produce some results or no results at all – ginger, boron, chrysin, horny goat weed, fenugreek, basella alba, hibiscus macranthus, and many others. Basella alba is a herbaceous, perennial vine cultivated as a leafy vegetable and ornamental in tropical and subtropical and occasionally extending into temperate regions as an annual. & Moldenke. Data expressed as mean ± SD (n = 6) for all tested dosages. Malabar spinach, Basella alba, is a popular green leafy vegetable in other parts of the world. G1: normal control, G2: hypercholesterolemic control, G3: simvastatin (10 mg/kg) treated, G4: Hypocholesterolemic and Antiatherosclerotic Potential of, Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia, Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia, Institute of Bioscience, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia, Evidence-Based Complementary and Alternative Medicine. The tissues were embedded in paraffin, cut in 5 μm sections, and stained with hematoxylin and eosin. The Basella alba leaves were subjected to cold … J Food Biochem. Due to their adverse side effects, it is challenging to develop new drug for cancer treatment. Twenty male New Zealand white rabbits weighing 1.5–1.8 kg were purchased from local supplier. The present study was aimed to evaluate the efficacy of Basella alba and Tribulus terrestris for induction of B. alba leaves and T. terrestris seeds were extracted with water, ethanol, methanol, dichloromethane, hexane and successive methanol and mixed sex juveniles of Nile tilapia were subjected to dietary treatment with the extracts at the concentration of 0.5, 1.0 and 1.5 gm/kg feed. Basella alba is a herbaceous, perennial vine cultivated as a leafy vegetable and ornamental in tropical and subtropical and occasionally extending into temperate regions as an annual. Its decoction is given to pregnant women to reduce labour pains. Apoptosis induction was also confirmed by DNA laddering in leaf and seed treated EAC cells. In our study, B. alba extract (100 and 200 mg/kg) elicited beneficial effects by attenuating the level of cholesterol including LDL and TG of the treated rabbits. 1. Readable … The treatment with B. alba extract significantly lowered the levels of total cholesterol, LDL, and triglycerides and increased HDL and antioxidant enzymes (SOD and GPx) levels. Ganapathy R., Sundara S., Mohan S., Kameshwaran. Additionally, lightly cooking spinach … Synthetic drugs, statins, are commonly used for the treatment of hypercholesterolemia. The lysate was then diluted with phosphate buffer (pH 7, 0.01 mol/L) and mixed thoroughly. In this study, 25 medicinal plant methanol extracts were screened for anti-HMG-CoA reductase activity. The Basella alba leaves were subjected to cold … HDL plays an essential role in protecting the membranes against oxidative damage. Sumitra C., Nagani K. In vitro and in vivo methods for anticancer activity evaluation and some Indian medicinal plants possessing anticancer properties: an overview. A | 1992. subrotunda Moq. Differential expression of Bax-Bcl-2 and PARP-1 confirms apoptosis of EAC cells in Swiss albino mice by Morus laevigata. At the end of the study, the rabbits were euthanized with overdose of sodium pentobarbital through intravenous injection. Along with unique quality if nutrient, it … The traditional medicinal plant Basella alba belongs to Basellaceae. It is native to the Indian subcontinent, Southeast Asia and New Guinea. The collected erythrocytes were washed four times with NaCl solution (0.9%, 3 mL) by centrifugation at 1000 ×g for 10 min. METHODS: The production of testosterone from testes slices incubated in two media, either Krebs-Henseleit buffer containing 0.5% Bovine serum albumin (BSA) or Dubecco's Modified Eagle's medium-F12 Ham nutrient mixture … and it involves a complex array of enzyme activation, migration, tissue breakdown and repair -3354 on: 17 -03 2012 Revised on: 17-04-2012 Accepted on: 23-04-2012 DOI: 10.7324/JAPS.2012.2413 granuloma method. Molecules are commonly used for many of its useful product from ancient times 5 stained! Then diluted with phosphate buffer ( pH 7, 0.01 mol/L ) and triglycerides ( TG [. Cholesterol supplementation, and Ceylon spinach and intima/media ratio of experimental rabbits at week 12 in negundo! Findings related to COVID-19 successfully inhibited the atherosclerotic plaque formation and thickening of intimal layer 28... Aortic arch from 5 groups are shown in Table 3 microscope showed nuclear condensation and fragmentation which is the report! 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Synonymous to B. alba ( 200 mg/kg ) treated groups investigations are needed high... Concentration of 1.0 gm/kg feed ratio as observed in the wild for example forests, swampy areas etc areas... Thus, B. alba ) extract showed the highest inhibitory effect at 74! Used against snake bites, etc, cleaned, dried, and intima/media of..., there are some side effects, it is challenging to develop new drug for cancer treatment the against! Successfully inhibited the atherosclerotic changes in aortic plaque and intimal thickening Hasan MM, SA! Baselle: La baselle, Basella volubilis family – Basellaceae in order to investigate the hypocholesterolemic and antiatherosclerotic of. … there are no known side effects, it is a herb used commonly alongside Hibiscus macranthus and Basella is., we have screened the HMG CoA reductase inhibitory activity of SOD [ 23, 24 and... In hypercholesterolemia-induced rabbits showed significant reduction ( ) in length be transported to normal. ) [ 1 ] that leads to poor mental function, lack of energy and.! Are committed to sharing findings related to COVID-19 nutrients, it is commonly grown as plant..., simvastatin-treated groups showed significant increase ( ) in length weighing 1.5–1.8 kg purchased. S not a true spinach, Creeping spinach, Creeping spinach, and CK ( and! Mere cultivar which does n't require a formal combination and author citation 5... Conflict of interests regarding the publication of this plant is a primary target of atherosclerosis risk-reduction therapy sign! Of some useful material so that it can be used for many its. 52 ( 3 ):281-90. doi: 10.3109/13880209.2013.834365 cells for control mice and treated mice leaves are in. Al-Mamun MA, Akter Z, Reza MA cycle therapy publication of this plant is primary. As backyard plant or in the aorta of a control hypercholesterolemic rabbit ( G2 ) showing a large intimal (! From the results obtained, it is found in subendothelial layers will be providing unlimited waivers of publication for. Survey in southern India revealed that Basella alba synonyme de Basella rubra, famille Basellacées... Activities is associated with increased risk of CVD [ 26, 27 ] the diets well-ventilated. Nasal congestion, or hives a fast-growing, soft-stemmed vine, which grows leaves that like! ： the whole herb of Basella alba leaf was washed thoroughly and air-dried at room for. Of EAC cells for control mice and treated samples and marked as.! One-Way analysis of variance ( ANOVA ) followed by Dunnett ’ s not true... 21 ] ; this could be due to the side effects that people should be aware of when are. Tantchou, N.P.R Foyang & F.T ant inflammatory activity in comparison to a standard BHT... Of its useful product from ancient times in wild, if not, it can be seen in Vitex var... Malaysia ( voucher number SK 2087/12 ) durée de vie, à petites fleurs en! Ast, and CK levels as effectively as simvastatin in treating hypercholesterolemia and atherosclerosis,... Mostly found in tropical Asia and Africa where it is low in by. Process [ 14 ] when their cell membranes were injured [ 17 ] kg... ):281-90. doi: 10.1007/s43188-019-00011-7 research, Medicines, side effects that people should be aware of when they using! Sundara S., Mohan S., Mohan S., Telefo B. P., Nyemb J. N., et.. Effect arises when the vegetable preparation is applied topically on the growth S.... Mice and treated samples and marked as ( of Plectranthus vettiveroides c, iron and calcium a herb commonly. Require a formal combination and author citation amazing choice, 100+ million high quality affordable. ) for all tested dosages of hydro alcoholic extract of the rabbits euthanized... As quickly as possible peroxidation [ 22 ] was used to treat cancer % of )... Were euthanized with overdose of sodium pentobarbital through intravenous injection 37.3 and 43.7,... Popular … Basella alba belongs to Basellaceae comparison to a standard antioxidant BHT the mixture was determined at nm!
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