Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide EC Number: 278-355-8 EC Name: Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide CAS Number: 75980-60-8 Molecular formula: C22H21O2P IUPAC Name: (diphenylphosphoroso)(2,4,6-trimethylphenyl)methanone Provisional Peer Reviewed Toxicity Values for . The chemical features of brigatinib are responsible for its properties like expanded fluid solvency, diminished lipophilicity and decreased protein binding ( Huang et al., 2016 ). In agreement with its logPow of 3.1, only 12mg can be dissolved in one liter of water. Phosphine is a super- toxic gas with a probable oral lethal dose of 5 mg/kg or 7 drops for a 150 pound person. Animal owners and veterinary staff members must be cautious while inducing emesis, because they can be exposed to phosphine gas from the presence of zinc phosphide bait in the stomach contents after vomiting. Cincinnati, OH 45268 Phosphine gas is a public health hazard. Diphenyl(2,4,6-trimethylbenzoyl) phosphine oxide (TPO) is used as a key processing aid in form of a chemical photo-initiator for polymerisation in artificial nail systems, primarily in UV-curable one-component gel systems. U.S. Environmental Protection Agency . As there is no suitable chemical to replace phosphine, it is essential to understand the mechanisms of phosphine toxicity to increase the effectiveness of resistance management. Triphenylphosphine oxide Revision Date 18-Jan-2018 11. Phosphine is … It may form mixtures with air that do not autoignite, but are flammable or explosive. The selectivity profile of brigatinib over ALK has been shown to be due to the dimethyl phosphine oxide moiety only. May produce highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. The development of high-level resistance in insects now threatens its continued use. National Center for Environmental Assessment . Phosphine Safety Data Sheet P-4643 This SDS conforms to U.S. Code of Federal Regulations 29 CFR 1910.1200, Hazard Communication. Phosphine's immediate health hazards are that it is a toxic gas and may cause thermal burns. Fumigation with phosphine gas is by far the most widely used treatment for the protection of stored grain against insect pests. Triphenylphosphine oxide (CASRN 791-28-6) Superfund Health Risk Technical Support Center . The … Toxicological information Acute Toxicity Product Information Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation Phosphine oxide, triphenyl- LD50 = 685 mg/kg ( Rat ) Not listed Not listed Toxicologically Synergistic Products No information available Office of Research and Development . 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