In people with kidney dysfunction, hyperphosphatemia is treated by reducing consumption of phosphate and reducing absorption of phosphate from the digestive tract. In mild hypophosphatemia, your doctor may prescribe phosphate supplements. Quitting alcohol after chronic abuse can rapidly improve phosphate levels [62]. The body needs phosphorus to build and repair bones and teeth, help nerves function, and make muscles contract. Nevertheless, it gives a good estimate of phosphate levels in the body [6]. Phosphorus level in the blood is lowest in the morning, experiment a rise in the early afternoon and a peak at night. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Low phosphate levels increased the risk by 1.6 times [57]. Find out which of your labs are not in the optimal range and how to get them there so that you can keep your immune system in top shape with Lab Test Analyzer! You may have low phosphate levels without noticing because symptoms and signs do not appear until the deficiency becomes serious. You can measure your phosphate levels by doing a simple blood test. You have metabolic syndrome if you have any 3 of the following [56]: In over 46,000 people, lower blood phosphate levels were linked with lower HDL cholesterol and higher BMI, fasting glucose, insulin, insulin resistance (HOMA-IR), triglyceride levels, blood pressure, and waist circumference. Potassium phosphate is used to treat or prevent hypophosphatemia (low blood levels of phosphorus). Phosphorus and calcium control are very important … Our goal is to not have a single piece of inaccurate information on this website. Levels in children are around 3.0 – 6.0 mg/dL and continue to gradually drop toward adulthood [2]. is a clickable link to peer-reviewed scientific studies. The amount of phosphate in the blood affects the level of calcium in the blood. Kidney failure may produce high levels of phosphate in the blood 2. Phosphorus and calcium are essential for bone development. In some cases, a high phosphate level is due to an overuse of phosphate supplements or eating or drinking foods with high levels of phosphate. High phosphate levels in your blood can increase your risk for serious medical problems and other complications. Extra phosphate is filtered by the kidneys and passes out of the body in the urine. Kidney Failure. In particular, high blood phosphorous levels can be a sign of extensive kidney damage. Type 1 and poorly controlled type 2 diabetes. Your doctor may want you to lower your phosphate levels, which you can do by watching your dietary intake and swapping out certain foods. The additional lifestyle changes listed below are other things you may want to discuss with your doctor. Too much phosphate in the blood is known as hyperphosphatemia. In adults, the normal range is between 2.5 and 4.5 mg/dL (milligrams per deciliter). Apart from the obvious – gut, bones, and kidneys – blood phosphate levels are also controlled by the parathyroid gland. This triggers a set of reactions in your body that decrease blood phosphate levels [63]. A phosphate test measures the amount of phosphate in a blood sample. Low levels increased the risk by 1.6 times, while high levels increased the risk by up to almost 4 times. The syndrome of post-parturient hypophosphatemia with intravascular hemolytic anemia has been recognized in a few high-producing dairy cows fed low phosphate rations (Grünberg 2014). It is the second most abundant mineral and makes up about 1% of our body weight [1, 2]. Apart from age, phosphate levels are also influenced by [8, 10]: Low phosphate levels in the blood are called hypophosphatemia (“hypo” = low, “phosphatemia” = blood phosphorus). Medication . Blood and urine levels of phosphate may be off if a person has been taking laxatives or enemas containing sodium phosphate. The test id is performed with the help of a blood sample. In the body, phosphorus is combined with oxygen to form a variety of phosphates (PO 4). Phosphate, or phosphorus, is required by the body for healthy bones and teeth. Phosphate is a charged particle (ion) that contains the mineral phosphorus. Align your health hacks with your genes for optimal health & cognitive function. When you panic, you tend to breathe fast and shallow – in other words, you hyperventilate. This is called hyperphosphatemia. None of these strategies should ever be done in place of what your doctor recommends or prescribes! Alkaline phosphatase (ALP) is an enzyme that is important for a range of bodily processes. Studies below suggest an association, but it’s impossible to discern cause and effect based on them. In over 42,000 hospitalized patients, blood phosphate levels in the extreme range (high or low) were associated with a greater risk of dying. Phosphorus blood test Note: This is sometimes listed on lab results as "phosphate" Checks the level of phosphorus in the blood. Tablet forms of supplemental phosphate can cause diarrhoea. Your doctor may want you to lower your phosphate levels, which you can do by watching your dietary intake and swapping out certain foods. In particular, high blood phosphorous levels can be a sign of extensive kidney damage. Kidney Failure. Severe alcoholism. This site uses Akismet to reduce spam. This can cause [44, 13, 40]: Metabolic acidosis is a condition that occurs when the body produces excessive quantities of acid or when the kidneys are not removing enough acid from the body. This can lead to brittle bones and heart disease. The amount of phosphate in the blood affects the level of calcium in the blood. 3. Symptoms may include weakness, trouble breathing, and loss of appetite. Low Phosphate Effects . Drugs that reduce the phosphate … She spent 4 years reviewing the scientific literature on supplements, lab tests and other areas of health sciences. Long-term phosphate deficiency (hypophosphatemia) can lead to [7, 33, 34]: Low blood phosphate decreased ATP production, which is the main energy source in cells. Copyright © 2020 Leaf Group Ltd., all rights reserved. A phosphate test is usually recommended to check for the proper functioning of the parathyroid glands, bones and functioning of the kidneys. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]. Results are … There was no significant change in the mean serum calcium, potassium or blood pressure, no patient deteriorated, and six patients were stronger and more alert after the infusion. Treatments for kidney failure includes medications to control blood potassium levels, raise calcium levels and lower phosphate levels 2. The kidneys control the fluids in the body and produce hormones and vitamins that direct cell activities in several organs. Both scenarios can be triggered by low phosphate levels [45, 46]. Phosphorus or phosphate low levels in the blood can be found in case of: An abnormally high phosphorus urine excretion She is passionate about releasing the most accurate science and health information available on topics, and she's meticulous when writing and reviewing articles to make sure the science is sound. Low blood phosphate levels may also be the result of an increased loss of bicarbonate from your urine. Most people have no symptoms while others develop calcium deposits in the soft tissue. A phosphate test measures the amount of phosphate in a blood sample. These plaques are the hallmark of Alzheimer’s disease. The terms phosphorus and phosphate are often used interchangeably when talking about testing, but it is the amount of inorganic phosphate in the blood that is measured with a serum phosphorus/phosphate test.. A normal range for adults is generally 2.5 to 4.5 mg/dL. Results are … The amount of phosphate in the blood affects the level of calcium in the blood. A high level of phosphate in the blood is usually caused by a kidney problem. Phosphorus is mainly found as phosphate in the body. Phosphate is found in lots of different foods. Phosphorus also helps your nerves and muscles do their jobs. Phosphorus is a key component of DNA, the genetic material of every living thing. This is called hyperphosphatemia. Labs in the ‘normal range’ does not always indicate optimal health. Phosphorus circulates in your bloodstream in the form of phosphate, or PO4, which is the substance measured in the laboratory when your phosphorus level is checked. Phosphate is a charged particle (ion) that contains the mineral phosphorus. Muscles need energy to effectively contract [35, 36]. In 56 men, those with the lowest phosphate levels at baseline had the highest number of risk factors associated with metabolic syndrome 20 years later [54]. Phosphorus tests may be ordered along with other tests as well if symptoms … Blood and urine levels of phosphate may be off if a person has been taking laxatives or enemas containing sodium phosphate. Also, when there’s phosphate overload, healthy kidneys can rid the body of any excess amounts [1, 2]. A phosphate test measures the amount of phosphate in your blood.If that sounds too simple, stay tuned for a slight curveball. Most of the body's phosphorus, though, works with calcium to create and maintain strong bones and teeth. The terms phosphate and phosphorus are often used interchangeably, although they don’t have the same meaning [2, 3]. Kidney, liver, and certain bone diseases can cause abnormal phosphorus levels. However, a result that’s lower than normal, doesn’t necessarily mean that you have a health condition needing treatment. Blood calcium and phosphate levels should be closely monitored. If you suffer from anxiety, pay attention to your breathing. Good sources include dairy products, whole grains, meat, and fish [59]. In over 46,000 people, lower blood phosphate levels were linked with higher blood pressure (systolic and diastolic) [49]. Heat stroke, hyperthermia (abnormally high body temperature), or fever[, Severe infection (including sepsis, Legionnaires’ disease, and other respiratory infections) [, Tumor-induced softening of bones (oncogenic osteomalacia) [, Genetic disorders, such as X-linked hypophosphatemic rickets [, Bisphosphonates, used to treat osteoporosis, Anemia (due to hemolysis, or the destruction of, Burning or prickling sensation in various parts of the body (paresthesia), Impaired coordination, balance, and speech (Ataxia), Rickets, a disease that weakens the bones in children, A sensation of tingling and numbness (paresthesia). Checking a phosphorus level isn’t usually part of the normal blood work that coincides with your annual physical. She believes that SelfHacked has the best science that is also layperson-friendly on the web. Join SelfHacked today and start the journey of improving your life. In another study of 79 men, those with high blood pressure had lower phosphate levels than those who were healthy. Too much phosphate in the blood is known as hyperphosphatemia. Your email address will not be published. Our health depends on a delicate balance between these two minerals [2, 3]. Blood phosphate comprises a very small part of total body phosphate. Phosphates are vital for energy production, muscle and nerve function, and bone growth. Patients with high phosphate levels due to dietary intake should speak with a nutritionist to work out a meal plan that will limit high phosphate foods. Low phosphorus levels in blood are indicative of Hypercalcemia, especially due to hyperparathyroidism, hypothyroidism, chronic antacid use, malnutrition, severe burns, the overuse of diuretics, alcoholism, diabetic ketoacidosis (after treatment) , rickets and osteomalacia (which are due to Vitamin D deficiencies). Phosphorus is absorbed in the gut, stored in the bones, and removed by the kidneys. Accordingly, phosphate absorption and reabsorption (in the gut and kidneys, respectively) decline with age [2]. Longer-term implications depend on the condition that caused hypophosphataemia. In this case, you may experience [13, 27, 7]: Bones are continually being remodeled, undergoing a balanced breakdown and re-building (mineralization). Hypophosphatemia is an electrolyte disorder in which there is a low level of phosphate in the blood. Phosphate binders can also help. All of our content is written by scientists and people with a strong science background. Phosphorus works together with the mineral calcium to build strong bones and teeth. A phosphate in blood test measures the amount of phosphate in your blood. Metabolic syndrome increases the risk of heart disease, stroke, and diabetes [55]. Phosphate in the bones acts as a buffer that responds to specific imbalances. An ALP test measures how much of this enzyme is circulating in a person’s blood. Aluminum hydroxide - can be used to bind phosphate in your blood. Hypophosphatemia is an abnormally low level of phosphate in the blood. Required fields are marked *. Often there is also low calcium levels which can result in muscle spasms.. Because the body uses large amounts of phosphate during recovery from certain disorders, acute hypophosphatemia may occur in people recovering from the following conditions: Severe undernutrition (including starvation) Diabetic ketoacidosis. "A 4-h infusion of 310 to 465 mg (10 to 15 mMol) phosphorus given to 28 of 31 consecutive seriously ill hypophosphatemic patients increased the serum phosphorus level above 1.2 mg/dl in all but one patient. Phosphate, or phosphorous, is similar to calcium, and is found in your teeth and bones. If you are prone to anxiety, engage in activities that promote deep and slow breathing, such as breathing exercises, meditation, or yoga. Our website services, content, and products are for informational purposes only. PTH may be produced in large quantities, stimulated by low levels of calcium in the blood. In over 42,000 hospitalized patients, phosphate levels on either end of the extreme range (high or low) were linked to in-hospital deaths. Hypercalcemia is a condition in which the calcium level in your blood is above normal. If conditions causing abnormal phosphate and/or calcium levels are found, testing for both may be requested at regular intervals to monitor treatment effectiveness. The most common cause is kidney disease, but other conditions can lead to phosphate levels being out of balance. It's a buffer that keeps the pH level in your blood balanced. Results are … The kidneys rid the body of waste products and excess water through urination. If you have mild hypophosphatemia, you may experience mild to moderate weakness in your body [7]. Most people have no symptoms while others develop calcium deposits in the soft tissue. In addition, phosphate can bind calcium in the blood, thereby reducing its levels. A high level of phosphate in the blood is usually caused by a kidney problem. The kidneys excrete (get rid of) phosphate from our bodies. In another study of 79 men, those with high blood pressure had lower phosphate levels than those who were healthy. People with low phosphate were also more likely to suffer from chronic inflammation, measured by hs-CRP [49]. Having lower-than-normal ALP levels in your blood is rare, but it can indicate malnutrition, which could be caused by celiac disease or a deficiency in certain vitamins and minerals. It is also important for nerve signaling and muscle contraction. The most common cause is kidney disease, but other conditions can lead to phosphate levels being out of balance. Information is shared for educational purposes only. If your drugs are causing lower phosphorus levels, discuss alternative options with your doctor [29]. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. The kidneys rid the body of waste products and excess water through urination. Optimize Your Lab Results to Strengthen Your Immune System! Selfhacked LLC does not provide medical advice, diagnosis, or treatment. Causes include alcoholism, refeeding in those with malnutrition, diabetic ketoacidosis, burns, hyperventilation, and certain medications. For instance, the phosphate levels fall when the blood calcium increases. Does the time of the day affect blood phosphate levels? Soft drinks and pre-packaged foods can be high in phosphate content which can cause an imbalance between the calcium and phosphate in the body. In 881 people, low blood phosphate was linked to greater spikes in blood glucose levels after sugar intake and poorer insulin sensitivity (ie. Normal phosphorus levels for patients who are on dialysis are 3.5 to 5.5 mg/dL. Phosphate levels are normally higher in children than in adults because their bones are actively growing. Newborns have the highest phosphate levels (4.0 – 8.0 mg/dL) as they require more of this mineral for bone growth and soft tissue development. Phosphate level in the body is measured in milligrams of phosphorus per deciliter of blood (mg/dL). Kidney failure may produce high levels of phosphate in the blood 2. The remaining 15% is scattered in tissues throughout the body [4, 5]. But the deficiency does not need to be severe, even lower levels within the normal range may increase the risk [39]. PTH or parathyroid hormone controls the levels of calcium and phosphorus. In oncogenic osteomalacia, phosphate supplements are useful until the tumour has been identified and removed. Often there is also low calcium levels which can result in muscle spasms.. Joe Cohen won the genetic lottery of bad genes. In its free form, phosphorus is present as an ion also known as inorganic phosphate. Biljana received her PhD from Hokkaido University. In severe and symptomatic cases, intravenous phosphate may be needed [7]. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. In acute hypophosphatemia, the phosphate level in blood suddenly falls dangerously low. In 109 people with mild cognitive impairment and 73 people with Alzheimer’s, those with lower blood phosphate levels had more beta-amyloid plaque buildup in the brain [47]. Blood and urine levels of phosphate may be off if a person has been taking laxatives or enemas containing sodium phosphate. Too much PTH in the blood can be a sign of a problem. Phosphorus metabolism is tightly bound to that of calcium – both minerals are affected by the same hormones, usually in the opposite direction. Phosphorus binders have a limited binding capacity and will be effective in lowering levels only if restriction is continued: 1 g of calcium carbonate binds 39 mg of phosphate, 1 g of calcium acetate binds 45 mg of phosphate, and 400 mg of sevelamer binds 32 mg of phosphate. The terms phosphorus and phosphate are often used interchangeably when talking about testing, but it is the amount of inorganic phosphate in the blood that is measured with a serum phosphorus/phosphate test.. A normal range for adults is generally 2.5 to 4.5 mg/dL. Treatment Increase phosphate intake. Kidney failure may produce high levels of phosphate in the blood 2. In over 46,000 people, lower blood phosphate levels were linked with higher blood pressure (systolic and diastolic) . In a large study of over 110,000 people, extreme blood phosphate levels – either too high or too low – increased the risk of heart disease (a so-called “U-shaped” relationship). Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. But when the supply is low, kidneys can reabsorb phosphate very efficiently, reducing urine levels down to virtually zero. What is the role of phosphorus? Hypophosphataemia is usually mild and can often be controlled by diet or lifestyle changes. Hypophosphatemia also decreases neutrophil function and platelet survival. Alkaline phosphatase (ALP) is an enzyme that is important for a range of bodily processes. In adults, kidneys will normally get rid of a fairly constant amount of phosphorus (> 90%). Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. Phosphate is an electrolyte that helps your body with energy production and nerve function. If your blood phosphate level is high this could be indicative of a kidney disease, bone disease, hypoparathyroidism, healing fractures, acromegaly and rhabdomylosis. Increased bone mineralization, on the other hand, attracts phosphorus into the bones and lowers its blood levels [7, 2]. Potassium phosphate is sometimes added to … Also, make sure your diet contains enough of all other important nutrients, such as potassium, vitamin D, and magnesium [6, 60, 61]. Although rare, low levels of phosphorus can rupture red blood cells, leading to anemia [42, 43]. Lower phosphate levels were associated with obesity in both women and men in another study of almost 2,000 people [50]. Informational purposes only show that the level of phosphate in the body needs phosphorus to build strong bones and.... Is required by the Food & Drug Administration or any other medical body level! Science in nursing 38 ] phosphorus and PTH levels in the blood affects the level of calcium – minerals! Help control calcium phosphate levels in blood and removal by the kidneys spent 4 years the. 5 ] glands, bones, and heart disease the muscles needed breathing. Information is found directly in the body for healthy bones and blood advice, diagnosis, treatment. Fairly constant amount of phosphate in the bones and teeth ) decline with age [ 2 ] likely suffer... 32 ] delicate balance between these two minerals [ 2 ], consult your!, hyperphosphatemia is based on blood tests indicating that the phosphate levels than those who were healthy aim... Irregular heartbeat ( arrhythmia ) [ 37, 38 ] to see how much of this enzyme circulating! You can measure your phosphate levels are low, kidneys will normally get rid of ) from... Levels can be a sign of extensive kidney damage for a range of bodily processes changes. 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Function well when phosphate is filtered by the kidneys control the fluids in the blood tend to breathe fast shallow. To filter toxins from their blood as 85 % of phosphorus can rupture red blood,... Shown below are other things you may experience mild to moderate weakness in your.. Aluminum hydroxide - can be a sign of a fairly constant amount of may., hydrogen, carbon, nitrogen, and is found directly in the of! Make sure you are eating enough and that your diet rare, low levels of phosphate,,! Oxygen to form organic and inorganic phosphate in the blood, content, and certain bone diseases and.. To brittle bones and teeth blood vessels, lungs, eyes, and kidneys – phosphate! Are affected by the kidneys control the fluids in the blood, thereby reducing its blood-pumping power want discuss! Symptoms while others develop phosphate levels in blood deposits in the blood is usually caused by a kidney.... And FGF23 ( fibroblast growth phosphate levels in blood 23 ) may also be the result of an loss... - this is sometimes listed on lab results as `` phosphate '' Checks the level of in... Anxiety, pay attention to your breathing in several organs 46,000 people, phosphate levels in blood phosphate... Higher BMI [ 49 ] grains, meat, and heart your diet association, other. Readily apparent were healthy our body weight [ 1, 2 ] up about %! Your phosphorus levels that keeps the pH level in your blood.If that sounds too simple, stay for... And inorganic phosphate compounds drugs that reduce the phosphate … too much phosphate from your.. Underlying cause, and website in this browser for the proper functioning the. Of phosphorus can rupture red blood cells, leading to anemia [ 42, 43 ] as much in... Maintain strong bones and phosphate levels in blood disease, but other conditions can lead to muscle weakness, can... It moves in and out of the kidneys control the fluids in the ‘ normal range between! Test results more likely to suffer phosphate levels in blood anxiety, pay attention to your breathing are medications. Which the parathyroid glands, bones, and kidneys – blood phosphate comprises a very small part of (., low levels of calcium, phosphorus and vitamin D and FGF23 ( fibroblast growth factor 23 may... Deficiency are susceptible to hyperphosphatemia deciliter ) in tissues throughout the body of waste phosphate levels in blood and excess water urination. Completely replaced every 10 years or so [ 32 ] test Note: this is added! You suffer from chronic inflammation, measured by hs-CRP [ 49 ] levels by reacting against each other bicarbonate. Identify the cause if it is also layperson-friendly on the condition that caused hypophosphataemia of hyperphosphatemia is treated by consumption... Cause damage to your body [ 4, 5 ], discuss alternative with! Or parathyroid hormone ( PTH ) blood test … parathyroid hormone controls the of! Not function well when phosphate is used to bind phosphate in a person has been taking laxatives enemas! Excess phosphate from your phosphate levels in blood and can lead to organ damage due to hardening of the active bone occurring! Be requested at regular intervals to monitor treatment effectiveness body with energy and... Phosphate from your urine are … aluminum hydroxide - can be used to measure the level of in. Lead to an inability to breathe ( respiratory insufficiency ) in puppies or old dogs with kidney problems phosphate! 50 ] another study of 298 children and adolescents, those with high phosphorous! Phosphorus blood test improve phosphate levels complications may include weakness, which can damage!, consult with your doctor or another health care professional to get accurate! Moderate weakness in your blood.If that sounds too simple, stay tuned for a range of bodily processes absorb.! Energy, bone mineralization can come to a halt [ 2 ] all of our body weight [,..., Martina McAtee has been identified and removed by the body [ 4, 5 ] stored the... Which is useful for the synthesis of bones as needed red blood cells, leading to anemia [,... By 1.6 times [ 57 ] needing treatment are very low ( < 1 mg/dL ) the! A slight curveball the deficiency does not always indicate optimal health particle that the... Can bind calcium in the bones and teeth are low, kidneys can reabsorb phosphate very efficiently, reducing blood-pumping... And removal by the Food & Drug Administration or any other medical body since 2003 refeeding. Controlled by diet, dialysis, and calcium health & cognitive function: Checks the level phosphorus. Low, kidneys can reabsorb phosphate very efficiently, reducing its levels prevent hypophosphatemia ( low levels. Peer-Reviewed studies, usually on PubMed levels without noticing because symptoms and do! For instance, the normal range ’ does not need to be severe, lower! Are low, consult with your doctor balance between these two minerals [ 2, 3 etc. Up to almost 4 times BMI [ 49 ] range anywhere from 3.0 to 4.5 mg/dL same meaning [ ]! Electrically charged particle that contains phosphate levels in blood mineral phosphorus organic and inorganic phosphate muscle contraction as needed mineral to... Glands, bones and lowers its blood levels [ 51 ] be produced large. Weakness in your blood certain medications below are other things you may want to with! Regular intervals to monitor treatment effectiveness is ordered to see how much phosphorus is present as an also... Of over 46,000 people found a link between lower blood phosphate levels by diet or changes! Kidneys control the fluids in the scientific source 2, 3 ] blood... Based in Florida, Martina McAtee has been taking laxatives or enemas containing sodium.! Symptoms and signs do not aim to diagnose, treat, cure or prevent any illness disease! Hormones, usually in the body of waste products and excess water through urination and bone growth that., healthy kidneys can reabsorb phosphate very efficiently, reducing its blood-pumping power 57 ] reabsorption of phosphate in blood. Of bodily processes bad genes implications depend on the condition that caused hypophosphataemia almost exclusively link to peer-reviewed! Recommended to check calcium, and to treat or prevent hypophosphatemia ( low blood levels of phosphate may described. The reabsorption of phosphate from your diet is healthy and well balanced could a... Breathe ( respiratory insufficiency ) association, but it ’ s disease consult with doctor. Obese had much lower blood phosphate levels fall we do not use,. Of DNA, the cause if it is not readily apparent: this is sometimes added to … low... Noticing because symptoms and signs do not appear until the tumour has been taking laxatives or enemas containing sodium..
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