of arsenic compounds to arsine is the primary mechanism for gaseous loss of arsenicals from solid. 2014 Sep;47(5):245-52. Johns, and M.F. CDC twenty four seven. Most reported cases of exposure to arsine have occurred during the smelting and refining of metals. Total arsenic in whole blood and hematocrit (Ht) values were measured. Careful work history on individuals with a painful peripheral neuropathy 2. Inorganic arsenic is found in nature at low levels mostly compounded with oxygen, chlorine, and sulfur. Arsenic trioxide is now used to treat acute … J Prev Med Public Health. Stibine (SbH3; hydrogen antimonide; antimony hydride; antimony trihydride)- Antimony (Sb) can be converted to stibine by a similar series of reactions required to convert arsenic to arsine. Arsine is similar to a gas called stibine, which is formed when the metal antimony comes in contact with an acid. Observed ECG changes regressed after arsenic exposure ceased. The term arsine is commonly used to describe a class of organoarsenic compounds of the formula AsH3−xRx, … Later, with another insecticide, superphosphate was added to create an acid medium, thereby leading to arsine production. 2005 Jul-Aug;71(4):230-5. doi: 10.4103/0378-6323.16612. Arsine usually evolved when nascent hydrogen was generated in the presence of arsenical compounds or by the hydrolysis of a metallic arsenide in contact with water. | NLM ... Arsenic (As) toxicity is a global phenomenon, and it is continuously threatening human life. Current OSHA PEL: 0.05 ppm (0.2 mg/m3) TWA 1989 OSHA PEL: Same as current PEL 1993-1994 ACGIH TLV: 0.05 ppm (0.16 mg/m3) TWA Description of substance: Colorless gas with a mild, garlic … Hocken, A.G., and G. Bradshaw: Arsine Poisoning. The tank had been used 6 months previously for the transport of a 42% solution of sodium arsenite (weed killer). The Mean Lethal Dose (MLD) is unknown for man, but in small mammals it is about 0.5 mg/kg body weight.6, The characteristic features of acute arsine poisoning are abdominal paint bloody urine, and jaundice (yellow discoloration of the skin). (1946), 1, 287. Arsine is a highly toxic gas that is generated upon exposure of arsenic–containing ores to acids, and it is a by–product of refining of non–ferrous metals. Before assigning the trailer to another client, a thorough cleaning job was ordered, which required the hand application of the acid cleaner. The aluminum ladder reacted with the sodium arsenite, liberating arsine. Most cases of arsine poisoning have been associated with the use of acids and crude metals, one or both of which contained arsenic as an impurity. This flammable, pyrophoric, and highly toxic pnictogen hydride gas is one of the simplest compounds of arsenic. Arsenic (As) is a nearly tasteless odorless toxic metalloid element that is found ubiquitously in the environment. Conrad, M.E., R.M. Putman: Arsine Poisoning Country Style. Rathus, E., R.G. NIOSH would like to inform the occupational health community of some of the circumstances in which workers have been poisoned by arsine, with particular emphasis on the underlying mechanisms of generating the gas. The fate of arsenic in soil-plant systems. Arsine vormt de basis voor een grote … When nascent hydrogen is generated in the presence of arsenic, or when water reacts with a metallic arsenide, arsine evolves. Bulmer, F.M.R., H.E. The exposed victims experienced shortness of breath on exertion, and a general feeling of weakness. Arsenic exposure is usually associated with suicide, malicious intent, homicide, or occupational exposure. Since that time it had been cleaned with steam and detergent, and used for storage and transportation of alcohol and other industrial solvents. 2012;215:1-37. doi: 10.1007/978-1-4614-1463-6_1. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Environmental source of arsenic exposure. 1979 Oct;40(10):A56-61. This was manifested by a progressive drop in the number of red blood cells and in the hemoglobin level. Saving Lives, Protecting People, The National Institute for Occupational Safety and Health (NIOSH), Current Intelligence Bulletin 32: Arsine (Arsenic Hydride) Poisining in the Workplace, National Institute for Occupational Safety and Health, U.S. Department of Health & Human Services. Arsine was generated by reducing arsenic trioxide with NaBH₄. In industrial settings arsine poisoning generally results from the accidental formation of arsine gas. Olsen V, Mørland J. Arsine fumes were generated by moisture reacting with aluminum arsenide in metal dross. [signature] In most situations where arsine can be formed stibine can also be formed if antimony is present. An unusual bronze discoloration of the skin can often be observed accompanying the jaundice. This site needs JavaScript to work properly. Arsine MAK value (1999) not yet established, see Section IIb of the List of MAK and BAT Values Absorption through the skin – Sensitization – Carcinogenicity – Prenatal toxicity – Germ cell mutagenicity – BAT value – Synonyms arsenic trihydride hydrogen arsenide Chemical name (CAS) arsine CAS number 7784-42-1 Structural formula AsH 3 Arsine may be accidentally formed by the reaction of arsenic impurities in commercial acids stored in metal tanks, so that a test should be made for arsine before entry is made into such vessels. Indian J Dermatol Venereol Leprol. Arsine is an inorganic compound with the formula AsH3. Arsine, ook bekend als arseentrihydride, is een bijzonder toxisch gas met als brutoformule AsH3, dat onder andere gebruikt wordt voor de synthese van halfgeleiders en forensisch onderzoek. Subsequently the mixture of water and sodium arsenite under these conditions led to the generation of arsine. Hillyer, and R.L. COVID-19 is an emerging, rapidly evolving situation. The worker’s risk of arsenic poisoning is therefore increased by the combination of inorganic arsenic exposure and the breakdown of arsine. Jenkins, G.C., J.E. Clipboard, Search History, and several other advanced features are temporarily unavailable. A worker was poisoned while cleaning an obstructed industrial drain which contained acid liquors with arsenic impurities. Stock.. A., and O. Guttmann: On Stibine and Yellow Antimony. Arsenic as a solute is nearly tasteless and can present in contaminated drinking water; it is also documented as a method of intentional homicide and suicide. However, in relation to the degree of blood destruction, the degree of known disability experienced by the victims of chronic arsine poisoning was less than expected.8, Chronic Arsenic Toxicity – Since inorganic arsenic is needed to generate arsine, prolonged exposures to low levels of arsine are likely to occur under conditions where workers are also exposed to inorganic arsenic. This estimate is not, however, based on actual workplace environmental exposure measurements. Frequently, patients exposed to arsenic have a garlic odor to their breath and tissue fluids. TABLE 1. Male 5-week-old Hos:HR-1 hairless mice were subjected to a single percutaneous exposure or whole-body inhalation exposure of ca. -, Yunus FM, Khan S, Chowdhury P, Milton AH, Hussain S, Rahman M. A Review of Groundwater Arsenic Contamination in Bangladesh: The Millennium Development Goal Era and Beyond. Lead alloys in car batteries contain antimony as a hardener, with arsenic and silver added to inhibit corrosion. Eight sailors were poisoned when a cylinder containing arsine developed a leak, emitting the gas into the airspace of a cargo hold on board a freighter. Anthony Robbins, M.D. Three workers were poisoned while using a jackhammer to remove slag from ladles. Registered trademark information is not included in these files. In W. Braker and A.C. Mossman: Kitzmiller, K.V., and R.A. Kehoe: Occupational Anemias. Contamination is caused by arsenic from natural geological sources leaching into aquifers, contaminating drinking water and may also occur from mining and other industrial processes. Common initial symptoms of exposure include malaise, headache, thirst, shivering, abdominal pain, and dyspnea. Arsine: Human health aspects. The NOHS estimate for occupational exposure to antimony is approximately l,7OO,OOO workers.5, The first case of arsine poisoning was reported in 1815 after a German chemist died from an exposure to arsine in his laboratory. Arsenic is present as a contaminant in many traditional remedies. Therefore, some of the above synonyms and identifiers may be trademarked but are not so indicated above. Arsine, the most toxic form of arsenic, is often produced from the reduction of inorganic arsenic salts with the use of acids and metal cofactors such as zinc. Arsine is a gas consisting of arsenic and hydrogen. 3rd ed., Volumes 1-26. Treasure Island (FL): StatPearls Publishing; 2020 Jan. Toxicol Ind Health. Secondary effects resulting from haemolysis include haemolytic anaemia, hepatic and renal damage. Hydrogen arsenide. Inorganic arsenic is metallic or a metalloid element that forms a number of poisonous compounds. Exposure also may occur from producing, cleaning, or reclaiming gallium arsenide wafers. TABLE 3. 2004 Nov 04;124(21):2750-3. Once arsine is inhaled, it breaks down, releasing inorganic arsenic into the blood stream. It has the ability to combine with hemoglobin within the red blood cell, causing destruction or severe swelling of the cell, rendering it nonfunctional.1 Inhalation of 250 ppm (800 mg/cu m) of arsine gas is instantly lethal. Identified in 1775, arsine is a highly poisonous, colorless, nonirritating gas with a mild garlic odor. Ley: Arsine Poisoning. It is extremely toxic to humans, with headaches, vomiting, and abdominal pains occurring within a few hours of exposure. The examination was performed 0-6 hr after the exposure. The above information was obtained from the National Institute for Occupational Safety and Health’s computerized Registry of Toxic Effects of Chemical Substances (RTECS), and from the National Library of Medicine’s computerized chemical dictionary file CHEMLINE. Case Reports – Most cases of arsine poisoning occur after the accidental generation of the gas in the workplace. Arsenic trihydride Food Addit Contam Part A Chem Anal Control Expo Risk Assess. Director, Current Intelligence Bulletin 32: Arsine (Arsenic Hydride) Poisining in the Workplace pdf icon[PDF – 699 KB], Centers for Disease Control and Prevention. During recycling, arsine can be released if scrap containing arsenic is melted down with the “maintenance-free” batteries containing calcium. General toxicity Arsine Arsine primarily targets the erythrocyte (red blood cell) and rapidly induces intravascular haemolysis. Although arsenic homicides commonly receive media publicity, the primary source of arsenic toxicity to the general population is by contaminated water, soil and food products. Arseniuretted hydrogen Two years before, arsenic had been used in the vat as an insecticide. : Personal communication, Lead Industries Association, New York, New York (June 14 and August 2, 1976). Chemical-specific health consultation for chromated copper arsenate chemical mixture: port of Djibouti. Arsenous hydride Stibine equals or surpasses arsine in toxicity, and causes a specific toxic action which closely resembles that of arsine.21 Although stibine is chemically similar to arsine, it is less stable. During recent years of may incidents have involved a reaction between arsenic and aluminum, with the subsequent release of hydrogen in the presence of water to permit the formation of arsine gas.9 Tables 1, 2, and 3 list examples of accidental arsine poisoning reported in the literature. Arsenate can replace phosphate in many reactions. The document states that the short-term limit is intended to achieve the greatest practicable reduction in worker exposure while avoiding spurious sampling results which can be produced by natural background concentrations of inorganic arsenic.3 The 1978 NIOSH criteria document on antimony recommended the retention of the specific Federal limit for occupational exposure to antimony, without recommending a limit for stibine.4, The NIOSH National Occupational Hazard Survey (NOHS) estimates that approximately 900,000 workers are occupationally exposed to identified sources of arsenic for varying periods of time during the workday. A more recent area of concern involves the recycling of batteries. taken for arsenic determination and since they are convenient to work with in statistically significant numbers. A worker was poisoned during reclamation of metal from flue dust obtained from blast furnaces. 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