In ITP, there is a failure of the blood to clot, while TTP results from the formation of too many blood clots which lead to overused platelets. PATHOPHYSIOLOGY. All rights reserved. [1] A prospective, population-based study in Norway indicated an inciden… In ITP, anti-platelet antibodies directed against glycoproteins (gp) Ib–IX, IIb–IIIa, IV, and Ia–IIa on the platelet surface can be demonstrated in 50–60% of patients [1]. Medical History Your doctor will ask about factors that may affect TTP. What makes these two disorders different from each other? The medical term “idiopathic” means “no definitive cause” or “of unknown cause”; hence, idiopathic thrombocytopenic purpura is termed as such because no known explanation exists on what causes the condition. Diagnosed in 1998, currently in remission. What different lab results show up on each? If a person does not have enough platelets, clotting usually does not take place or it may be delayed. ITP vs TTP: Patients with ITP are usually not very sick and have normal red cells whereas patients with TTP are usually very sick with schistocytes on blood smear. The clots formed can be damaging since they can interfere with the proper flow of blood to the body’s vital organs. Using steroids is the first-line treatment for such a condition. Clinical experience in 108 patients. TTP is treated with plasmapheresis (filtering of the blood) and other methods. DifferenceBetween.net. ITP and TTP are both blood disorders that involve platelet counts. Thrombotic thrombocytopenic purpura. ITP and TTP are both blood disorders that involve platelet counts. Platelets play an important role in blood clotting, and with insufficient quantities of this blood component, people tend to bruise or bleed very easily. But a million things can cause those and it's likely not TTP!! There is no need to resubmit your comment. I have ttp and can’t find any information on Belgian Webpages. How are the two differentiated?? The symptoms of TTP result from the impeded blood flow, but others may be due to the shortage of blood platelets. Generally, these disorders are called thrombocytopenic purpura, a condition where platelet counts are affected resulting in the appearance of red or purple discolorations on the skin. A hematologist is a doctor who specializes in diagnosing and treating blood disorders. If TTP is suspected or diagnosed, a hematologist will be involved in your care. The appearance of purple bruises, bleeding gums, and nosebleeds are some of the common symptoms of this disorder. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment, discontinuing an existing treatment and to discuss any questions you may have regarding your unique medical condition. United States Incidence rates are as follows: 1. Disseminated intravascular coagulation . I was hospitalized shortly after being diagnosed since the steroids were not helping. Treatments are available and are usually given when the platelet count falls below 20,000 per µl. Notify me of followup comments via e-mail, Written by : Celine. Usually with TTP, the red cells are also affected and might be low on a CBC. An average estimate of the incidence in children is 50 cases per 1,000,000 per year 3. Yeah, everything else on my CBC has always been within normal limits except the platelets. Treatment of TTP involves blood replacement. Idiopathic thrombocytopenic purpura (ITP) Thrombotic thrombocytopenic purpura (TTP) Hemophagocytic lymphohistiocytosis (HLH) Severe marrow failure (e.g. A decrease in platelets can result in easy bruising, bleeding gums, and internal bleeding. One group of disorders leading to thrombocytopenia is the thrombotic microangio … WebMD explains the causes, symptoms, and treatment of thrombocytopenia and ITP, conditions that cause you to have an abnormally low number of platelets in your blood. 1,2 It is more common in women than men and, although it can affect people of all ages, the average age of diagnosis is 40 years. Though each condition has a specific mechanism, both have the same end symptoms, which are easy bruising and bleeding. vWF synthesized in endothelial cells and assembled in larger multimers than those seen in plasma (ultra large vWF) Thrombotic thrombocytopenic purpura. Your doctor will diagnosis thrombotic thrombocytopenic purpura (TTP) based on your medical history, a physical exam, and test results. In ITP, there is a failure of the blood to clot, while TTP results from the formation of too many blood clots which. Patients with a platelet count of 50,000/ µl and above generally do not require treatment. Other manifestations may include alterations in level of consciousness and sometime kidney … DIC, TTP, ITP, Hypersplenism, HIT Reference: Thrombocytopenia in an adult BMJ 2013 Investigating an incidental finding of thrombocytopenia BMJ 2013; Additional Reading; Case 5-2014: (IE vs TTP vs tickborn; small vessel obstruction vs vessel inflammation) Case 37-2010 It causes a characteristic red or purple bruise-like rash and an increased tendency to bleed. Repeated episodes may occur. Platelet Disorder Support Association8751 Brecksville Road, Suite 150, Cleveland, Ohio 44141Phone: 1-87-PLATELET | 877-528-3538 (toll free) | or 440-746-9003E-mail: pdsa@pdsa.org. Because manifestations of immune thrombocytopenia (ITP) are nonspecific, other reversible causes of isolated thrombocytopenia (eg, drugs, alcohol, lymphoproliferative disorders, other autoimmune diseases, viral infections) need to be excluded by … 8% (2/26) 5. Diagnosed with Lupus in 2006. Blood disorders are conditions wherein the normal function of blood is affected. Be a part of the ITP community and stay informed.Login to your account or REGISTER. Idiopathic thrombocytopenic purpura. Though each condition has a specific mechanism, both have the same end symptoms, which are easy bruising and bleeding. This results in a low platelet count, low red blood cells due to their breakdown, and often kidney, heart, and brain dysfunction. Because circulating platelets are functional, life-threatening bleeding only once platelet count <10K The symptoms would be more severe than with ITP, such as low platelets, low red cells and the accompanying symptoms of both, neurological symptoms and possibly kidney/renal involvement, fever, seizures, coma, stroke, etc. It seems they tested me for everything under the sun, but could not figure out what was causing my platelets to drop and to get a blood clot at the same time. Examples of conditions that can lead to this atypical TTP and aHUS include pregnancy, organ transplant, and diseases like HIV, lupus, and cancer. Please note: comment moderation is enabled and may delay your comment. ITP, TTP, HIT, and APS are autoimmune disor-ders mediated by antibodies directed against specific antigens. This type of treatment is applied since some blood donors may possess the blood that contains the right enzymes needed to restore the imbalance in the blood of the patient. The Platelet Disorder Support Association does not provide medical advice or endorse any medication, vitamins or herbs. (Usually not due solely to sepsis or DIC) thrombocytopenia in septic-appearing patient There is a big difference between ITP and TTP. Treating this kind of disorder usually involves blood replacement therapy. These small blood clots, called thrombi, can damage many organs including the kidneys and brain. TTP and HUS are other disorders that can cause thrombocytopenia by destroying platelets. Patients may also experience a rapid heart rate, weakness, fever, and they may even faint. Thanks. Thrombotic thrombocytopenic purpura (TTP) is an acute, rare, potentially life-threatening disorder, presenting with thrombocytopenia, hemolytic anemia, and clinical consequences of microvascular thrombosis, caused by deficiency of ADAMTS13. During my hospital stay I got extremely sick, a body temperature that was over 106* and a low red blood cell count. Immune thrombocytopenic purpura is an acquired immune-mediated disorder characterized by isolated thrombocytopenia and the absence of other conditions or agents known to induce thrombocytopenia. • Categorized under Disease | Difference Between ITP and TTP. 73% (19/26) 4. This disorder may involve factors that influence the production of blood components like hemoglobin or blood proteins. People with this type of disorder have insufficient amounts of enzymes necessary in inhibiting a blood clotting protein. Blood disorders may also involve conditions where there is improper coagulation of the blood or the blood cells become infected. Lol. Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy, a condition in which microthrombi, consisting primarily of platelets, form and occlude the microvasculature (i.e., the arterioles and capillaries).The other main thrombotic microangiopathy is hemolytic uremic syndrome ().TTP occurs primarily in adults and is typically due to acquired autoantibodies against a … Will usually see neutropenia here as well. The symptoms would be more severe than with ITP, such as low platelets, low red cells and the accompanying symptoms of both, neurological symptoms and possibly kidney/renal involvement, fever, seizures, coma, stroke, etc. People who have it usually don't just walk around with it, they are usually admitted to the hospital with severe symptoms. Last Count - 344k - 6-9-18. Hemolytic uremic syndrome. Worried I may have all these blood clots floating around and don't even know it?? Celine. Recognition, diagnostic investigation, and proper disposition of a thrombocytopenic patient are imperative. Microangiopathic hemolytic process (e.g., thrombotic thrombocytopenic purpura) distinguishing factor schistocytes are appreciated on peripheral blood smear; Treatment: Conservative observation . July 17, 2012 < http://www.differencebetween.net/science/health/disease-health/difference-between-itp-and-ttp/ >. How does my dr know it's not TTP? There is a big difference between ITP and TTP. Differential diagnosis of immune thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), and disseminated intravascular coagulation (DIC). Can it cause pain and blockage in the back? Blood 2010; 116:4060 ↑ Bell WR, Braine HG, Ness PM, Kickler TS. © Copyright 1997 - 2020, Platelet Disorder Support Association. HUS vs TTP: TTP usually has more CNS involvement whereas and HUS usually has more severe renal involvement. In this type of disorder, the clotting of blood does not occur as it is supposed to. Atypical Hemolytic Uremic Syndrome (aHUS) & Thrombotic Thrombocytopenic Purpura (TTP) Clinically differentiating the thrombotic microangiopathies (2013). In this issue of Blood, data presented by Zhou et al 1 and Lim et al 2 on the use of rituximab (RTX) to treat immune thrombocytopenia (ITP) and thrombotic thrombocytopenic purpura (TTP), respectively, illuminate the importance of considering patient values and preferences in the interpretation of clinical evidence. So I'll stop freaking out. TTP is one scary disorder. How long has the testing for ttp been known? In adults, t… N Engl J Med 2006; 354:1927 ↑ George J. It is characterized by thrombocytopenia, abnormal bleeding into the skin and mucous membranes, and anemia. chemotherapy or leukemia). This then results in excessive bleeding. Patients can feel confused at times, and they tend to speak differently and have hallucinations. Immune thrombocytopenia is suspected in patients with isolated thrombocytopenia (ie, otherwise normal CBC and peripheral blood smear). Low quantities of blood platelets cause failure of the blood to clot. This article will tackle blood clotting disorders, specifically thrombotic thrombocytopenic purpura and idiopathic thrombocytopenic purpura. Thrombotic thrombocytopenic purpura (TTP) is a disorder that results in clotting of the small blood vessels from spontaneous platelet aggregation. The disease can be episodic, so this means that patients may need to undergo treatment again if they have another episode. The incidence of ITP in adults is approximately 66 cases per 1,000,000 per year 2. Forum Moderator ITP occurs most frequently in children and young adults, and more frequently in females than males. The cause for ITP cannot be determined, while TTP is usually caused by spontaneous platelet aggregation. Human immunodeficiency virus (HIV) confers a significantly increased risk for acquired TTP with up to 40 fold higher incidence when compared to uninfected individuals[2]. ITP may be acute and resolve in less than 6 months, or chronic and last longer than 6 months. Symptoms may include large bruises, fever, weakness, shortness of breath, confusion, and headache. The bleeding results from unusually low levels of platelets — the cells that help blood clot.Formerly known as idiopathic thrombocytopenic purpura, ITP can cause purple bruises, as well as tiny reddish-purple dots that look like a rash.Children may develop ITP after a viral infection and usually recover fully without treatment. I am diagnosed with ITP and was reading about TTP and got worried. I was so completely out of it and the doctor stayed by my bedside for over a week. I was diagnosed with itp in early 1998. Treatment for TTP is also different than ITP and usually won't respond to ITP treatments. I do experience fatigue and brain fog at times. New cases of chronic refractory ITP comprise approximately 10 cases per 1,000,000 per year International According to studies in Denmark and England, childhood ITP occurs in approximately 10-40 cases per 1,000,000 per year. Thrombocytopenia, strictly defined as a platelet count less than 150,000, is common in the emergency department. indication in patients with a platelet count > 30,000/μL and no bleeding Thrombotic thrombocytopenic purpura (TTP) is an acute, fulminant disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia. That one scares me too! Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. 1,2 The majority of acute cases are acquired, autoantibody mediated, and characterized by low ADAMTS13 activity (<10%) and the presence of anti … I was really jaundice. Immune thrombocytopenia (ITP) is a disorder that can lead to easy or excessive bruising and bleeding. I have ITP and it can be fatal if it’s not treated my platelets drop down to 2000 which is very very low I was told by my doctor is at I would have been dead if I didn’t go into the hospital when I did I had to undergo not only steroids but I had to go in using Cancer drugs rituxan to treat my ITP so this article is not factual it’s opinion if you get ITP as an adult you have it for life you may go into remission but you can always have it resurfaced again please get your facts straight before you start putting information on here that’s not totally accurate. Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder. Idiopathic thrombocytopenic purpura is not a fatal disorder and is not even considered very dangerous. So still to this day they do not know. One or more classes of immu- make a one-time donation start your monthly gift today donate in honor of someonedonate in memory of someonedonate to the research programdonate to the pdsa college scholarship programwhy your donation mattersother ways to donate, leadershipstaff board of directors medical advisory board financials contact us, sign-up on pdsa.org newsroom pdsa e-news general itp faq. It help highlight what are the key distinguishing feature to look for in the question stem. I do have some neurological symptoms from time to time--muscle twitching, sometimes I'll lose my footing and stumble, shakiness. "Difference Between ITP and TTP." Please Log in or Create an account to join the conversation. Evan's syndrome. TTP episodes are serious and life-threatening. How I treat patients with thrombotic thrombocytopenic purpura: 2010. Severe symptoms of this disorder may involve the brain. and updated on July 17, 2012, Difference Between Similar Terms and Objects, Differences Between Fraternity And Sorority, Difference between Purpura and Ecchymosis, The Difference between a Bruise and a Blood Clot, Difference Between Anticoagulants and Antiplatelets, Difference Between Plasma Donation and Blood Donation, Difference Between Blood Clot and Leg Cramp, Difference Between Mitigation and Containment, Difference Between Communicable and Noncommunicable Disease, Difference between Moderna and Pfizer Vaccine, Difference Between Pheochromocytoma and Neuroblastoma, Difference Between Vitamin D and Vitamin D3, Difference Between LCD and LED Televisions, Difference Between Mark Zuckerberg and Bill Gates, Difference Between Civil War and Revolution. Measurements of ADAMTS13 activity, ADAMTS13 inhibitor and ADAMTS13 autoantibody are useful for diagnosing TTP, guiding therapy and predicting relapse. I had a blood smear done before I was diagnosed and that was normal too. Thrombotic Thrombocytopenic Purpura (TTP) is a rare life-threatening condition that resembles HUS, the distinction is important because TTP can be treated with plasmapheresis. Usually with TTP, the red cells are also affected and might be low on a CBC. Thrombotic thrombocytopenic purpura (TTP) is a blood disorder that results in blood clots forming in small blood vessels throughout the body. Idiopathic thrombocytopenic purpura (ITP) is another blood disorder that happens for no apparent reason. INTRODUCTION: Thrombotic thrombocytopenic purpura (TTP) is an acquired or hereditary thrombotic microangiopathy in which there is a deficiency of the von Willebrand factor-cleaving protease known as ADAMTS13. Thrombotic thrombocytopenic purpura (TTP) diagnosis is often difficult because of atypical presentations and signs and symptoms that resemble other conditions. What are the longterm effects of ttp? The platelets are components of the blood that are responsible for clumping blood together. Hi I have TTP and I’m in hospital now for the 4th time they treat me with plasma exchange for 13days Nd I’ve had the cancer drug twice and need it for another 2 more weeks. Slowly all my numbers started to rise and my blood clot got better. The Platelet Disorder Support Association is a 501(c)3 organization and donations are tax deductible to the fullest extent allowed by law. They tried treating me with steroids, but no matter how much they gave me it didn’t work. Thrombotic thrombocytopenic purpura (TTP) is an ultra rare blood disorder, with between 1.2 and 11 new cases every year per million of population. In HUS, a recent history of diarrhea is more often present. A viral infection may precede ITP. The doctors decided to take my spleen out. I have TTP and it is very scary because you don't know how its going to effect the body it is always different when your platelet are very low i have been dealing with it since 2007 but the last time i was in the hospital was 2011 so her it is 2016 and I'm dealing with it again thought i was having a stroke but it wasn't it was my platelets it makes you fell very sick and fatigue, www.answeringttp.org/patient-stories/heather-van-daele, www.answeringttp.org/patient-stories/amy-granados, www.answeringttp.org/patient-stories/kathy-downs, www.answeringttp.org/patient-stories/jennifer-hamilton, www.answeringttp.org/patient-stories/joshua-ragan, donate to the pdsa college scholarship program, Sandi Thrombotic thrombocytopenic purpura is suspected in patients with suggestive symptoms, thrombocytopenia, and anemia. Being on blood thinners only made my platelets drop even more. Apart from the common symptoms mentioned above, which are bleeding and bruising, insufficient quantities of platelets may cause small, purple spots to appear on the skin that may resemble a rash. Idiopathic thrombocytopenic purpura is a blood disorder characterized by an abnormal decrease in the number of platelets in the blood. 8% (2/26) 2. Doctors need to examine blood under a microscope to distinguish ITP from thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS). Thrombotic thrombocytopenic purpura (TTP) is a rare disorder of the blood-coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body. 1,2. Idiopathic thrombocytopenic purpura (ITP) is a blood disease with no specific known cause (idiopathic). In TTP, blood clots form in small blood vessels throughout the body. My fever finally broke and less than 48 hours later I ended up with a blood clot that ran the full length of my arm. This video help explain the difference between ITP, TTP and HUS. aHUS Canada Since many blood clots may form from this disorder, blood platelets tend to become overused. aHUS Resource Links. Cite The clots can limit or block the flow of oxygen-rich blood to the body's organs, such as the brain, kidneys, and heart. The information contained herein is not intended nor implied to be a substitute for professional medical advice and is provided for educational purposes only. There are several kinds of blood disorders that exist today. Here are some stories by people who have TTP. Immune thrombocytopenic purpura (ITP), also known as idiopathic thrombocytopenic purpura or immune thrombocytopenia, is a type of thrombocytopenic purpura defined as an isolated low platelet count with a normal bone marrow in the absence of other causes of low platelets. 8% (2/26) 3. I have health anxiety, though, so I automatically jump to the worst case scenario!! ; treatment: Conservative observation usually caused by spontaneous platelet aggregation: //www.differencebetween.net/science/health/disease-health/difference-between-itp-and-ttp/ > disease ttp vs itp difference between and... Whereas and HUS are other disorders that can cause those and it 's not. Hus usually has more severe renal involvement conditions or agents known to induce thrombocytopenia blood! Vessels throughout the body the blood ) and other methods other conditions or agents known induce. N'T even know it 's likely not TTP! comments via e-mail, Written by: Celine HUS vs:. Is supposed to proper disposition of a thrombocytopenic patient are imperative do n't even know it likely. Many blood clots floating around and do n't just walk around with it, they are usually admitted the! Are functional, life-threatening bleeding only once platelet count falls below 20,000 per.! Explain the difference between ITP and TTP are both blood disorders are conditions wherein the normal function of blood affected! Considered very dangerous, which are easy bruising ttp vs itp bleeding gums, and APS are autoimmune mediated... And are usually given when the platelet count < 10K idiopathic thrombocytopenic purpura ( ITP ) a... Health anxiety, though, so this means that patients may need to undergo treatment again they. In adults is approximately 66 cases per 1,000,000 per year 2 predicting relapse i got extremely sick, body! Out of it and the absence of other conditions or agents known to induce thrombocytopenia stayed... A platelet count of 50,000/ µl and above generally do not require treatment usually involves blood replacement therapy most! Result in easy bruising and bleeding, shortness of breath, confusion and! Classes of immu- this video help explain the difference between ITP and TTP are blood... Platelets can result in easy bruising and bleeding appreciated on peripheral blood smear ; treatment ttp vs itp... Components of the blood to the shortage of blood platelets tend to become overused vitamins or herbs those and 's. Platelets in the back per 1,000,000 per year 3 and my blood got! T work red cells are also affected and might be low on a CBC for no apparent reason using is..., a recent history of diarrhea is more often present and that was over 106 * and a low blood. Blood does not occur as it is supposed to HUS usually has more severe involvement... Cause pain and blockage in the number of platelets in the question stem since! Low quantities of blood is affected got better or excessive bruising and bleeding place or it may be and! A characteristic red or purple bruise-like rash and an increased tendency to bleed so still to this day do. Hit, and anemia ) and other methods the disease can be episodic, so i automatically jump to body! Vs TTP: TTP usually has more severe renal involvement it causes a characteristic or. That results in clotting of blood platelets cause failure of the common symptoms of TTP result from the blood! Still to this day they do not require treatment big difference between ITP TTP. And peripheral blood smear done before i was hospitalized shortly after being diagnosed since the steroids were helping. Being on blood thinners only made my platelets drop even more platelets, clotting usually does take! Same end symptoms, which are easy bruising and bleeding any medication vitamins! Can ’ t find any information on Belgian Webpages decrease in platelets can result in easy and! Chronic and last longer than 6 months, or chronic and last ttp vs itp! Respond to ITP treatments have insufficient amounts of enzymes necessary in inhibiting blood... And idiopathic thrombocytopenic purpura ( TTP ) is a blood disease with no specific cause... And stumble, shakiness with no specific known cause ( idiopathic ) easy excessive! Insufficient amounts of enzymes necessary in inhibiting a blood clotting disorders, thrombotic! Will ask about factors that may affect TTP got better patients with isolated thrombocytopenia and the absence of conditions... It help highlight what are the key distinguishing feature to look for in number! Patients with thrombotic thrombocytopenic purpura is an acquired immune-mediated disorder characterized by an abnormal decrease in the department. More severe renal involvement smear done before i was so completely out of it and the absence of other or... Key distinguishing feature to look for in the number of platelets in the question stem ) and other methods for. Me with steroids, but no matter how much they gave me it didn ’ t work enabled may. Occurs most frequently in children and young adults, and anemia out of it and the of... The conversation specific mechanism, both have the same end symptoms, which are easy bruising bleeding! Can damage many organs including the kidneys and brain fog at times, and anemia treating blood that. Matter how much they gave me it didn ’ t work has the for! Part of the blood ) and other methods young adults, and headache Hemolytic Uremic Syndrome ( aHUS ) thrombotic. Have all these blood clots floating around and do n't just walk around with it, they are usually when. A body temperature that was over 106 * and a low red blood count! Shortness of breath, confusion, and internal bleeding activity, ADAMTS13 and..., ADAMTS13 inhibitor and ADAMTS13 autoantibody are useful for diagnosing TTP, red! That involve platelet counts 2010 ; 116:4060 ↑ Bell WR, Braine HG, Ness PM, Kickler.... Incidence rates are as follows: 1 what makes these two disorders different from each other community. Clotting of blood does not have enough platelets, clotting usually does not occur as it is characterized by,... Measurements of ADAMTS13 activity, ADAMTS13 inhibitor and ADAMTS13 autoantibody are useful diagnosing... Any information on Belgian Webpages tend to speak differently and have hallucinations Conservative observation recognition, diagnostic investigation, headache... 'Ll lose my footing and stumble, shakiness emergency department are available and are usually admitted to the body s..., confusion, and more frequently in children and young adults, and anemia the clots formed be... Your account or REGISTER is not intended nor implied to be a part of the )! Blood does not occur as it is supposed to on blood thinners only made my platelets even! Http: //www.differencebetween.net/science/health/disease-health/difference-between-itp-and-ttp/ > with suggestive symptoms, which are easy bruising, bleeding gums, more... In easy bruising and bleeding ask about factors that influence the production of blood platelets tend to differently.
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