R. B. Lauffer, A. C. Vincent, S. Padmanabhan, A. Villringer, W. L. Greig, D. Elmaleh and T. Brady. K. N. Raymond, S. S. Isied, L. D. Brown, F. R. Fronczek, J. H. Neibert. The vast array of information available for their bioinorganic properties and mode of action in several biological systems, combined with the new opportunities offered by the flourishing technologies of medicinal chemistry, is creating an exciting scenario for the development of … In contrast to 1999, when the only reference to medicinal applications of catalytic metal complexes was to mimic the enzyme superoxide dismutase, today a broad variety of “unnatural” molecular transformations can be effected inside living cells, with many more on the horizon. Cite as. Z. Gougoutas, M. R. Malley and A. D. Nunn. V. M. Runge, J. B. Smith and M. M. Jones. Metal complexes of CLN such as [Me(CLN)2][HgI4] where Me = Cd(II), Mn(II), Ni(II), and Cu(II) were synthesized and studied by elemental analysis, FTIR spectroscopy, Raman spectroscopy (Figure 13), and EPR spectroscopy confirming the structure and the changes in the complex conformation [28]. 186, American Chemical Society, Division of Inorganic Chemistry, 208th ACS National Meeting, Washington, D.C., August 20–25, 1994. A. E. Martell, R. J. Motekaitis; I. Murase, L. F. Sala, R. Stoldt, C. Y. Ng, H. Rosenkrantz and J. J. Metterville. S. W. Schwarz, C. J. Mathias, Y. [Article in Hungarian] Nagy L(1), Csintalan G, Kálmán E, Nagy E, Sipos P. Author information: (1)Szegedi Tudományegyetem, Szervetlen és Analitikai Kémia Tanszék, Szeged. The fundamental role of copper and the recognition of its complexes as important bioactive compounds in vitro and in vivoaroused an ever-increasing interest in these agents as potential drugs for therapeutic intervention in various diseases. Sun, A. E. Martell, J. H. Reibenspies and M. J. Welch. Metal complexes can be used either for radioisotope imaging (from their emitted radiation) or as contrast agents, for example, in magnetic resonance imaging (MRI). application. Transition metals complex under goes a series of reactions that are generally unlike those main group compounds. M. Wilhelm, D. E. Jager and F. K. Ohnesorge. L. K. Templeton, D. H. Templeton, A. Zalkin, and H. W. Rubin. H. V. Aposhian, D. E. Carter, T. D. Hoover, C.-H Hsu, R. M. Maiorino and E. Stein. D. R. Burton, S. Forsen and G. Karlstrom. We here review the properties of five metal complexes as anticancer agents and make comparisons among them in biological features and cytotoxic activity. W. Bauer, U. Brimer, W. Doepfner, R. Haller, R. Huguenin, P. Marbach, T. J. Petcher and J. Pless. M. L. Thakur, R. E. Coleman and M. J. Welch. Coordination complexes and transition metals are an integral component of proteins, especially the class of proteins that can perform chemical reactions, called enzymes. E. C. Weiner, M. W. Brechbiel, H. Brothers, R. L. Magin, O. Built by scientists, for scientists. 12–13, 1993, University of Milan. Raman spectra of CLN and of its metal complexes. R. Delgado, Y. Previous chapters have emphasized the factors involved in designing metal complexes with maximum stability, and with a large degree of selectivity. I. S. Kojima, K. Kaminaka, M. Kiyozumi and T. Honda. P. W. Durbin, E. S. Jones, K. N. Raymond and F. L. Weitle. In fact, many of the basic components of living organisms (amino acids, peptides, proteins, hormones, lipids, carbohydrates, etc.) Download preview PDF. The spectral methods such as Fourier transform infrared spectroscopy, Raman spectroscopy, surface-enhanced Raman spectroscopy, X-ray spectroscopy, mass spectrometry, ultraviolet-visible spectrophotometry, electron paramagnetic resonance spectroscopy, and X-ray diffraction provided information about the complexes and ligand structure. Contrast agens in diagnostic. G. J. Kontoghiorghes and A. V. Hoffbrand. There are a number of ways in which coordination compounds are used in the analysis of various substances. R. Ma, J. Reibenspies, M. J. Welch and A. E. Martell. J. Baldas, J. R. Boas, J. Bounyman and G. A. Williams. Sun, A. E. Martell and M. J. Welch. Available from: Physicochemical characterization of metal complexes of some pharmaceuticals, Biomedical significance of metal complexes with pharmaceuticals, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania. Surprisingly, silver is not dealt with, even though it is a very effective antibacterial agent. A. Gansow, D. A. Tomalia, P. C. Lauterbur, © Springer Science+Business Media New York 1996, https://doi.org/10.1007/978-1-4899-1486-6_5. Coordination compounds are a class of compounds that we know as the complex compounds. Tao, X.-H. Xu, X.-M. Yan, Z.-J. 1. R. M. Smith, A. E. Martell and R. J. Motekaitis. Sun, W. G. Dilley, S. A. It is the purpose of this chapter to use the principles that have been described in previous chapters on metal complexes, chelates, and macrocyclic compounds to develop an understanding of the use of metal complexes or ligands for medical purposes. E. Deutsch, K. Libson, J.-L. Vanderheyden, A. R. Ketring and H. R. Maxon. Such imaging can be enhanced by manipulation of the ligands in a complex to create specificity so that the complex will be taken up by a certain cell or organ type. A. Clanton and D. M. Lukehart. C. J. Anderson, C. S. John, Y. J. Li, R. D. Hancock, T. J. McCarthy, A. E. Martell and M. J. Welch. Transition metals, role and therapeutic potential. 1–12. D. J. P. W. Durbin, N. Jeung, S. J. Rodgers, P. N. Turowski, F. L. Weitle, D. L. White and K. N. Raymond. B. Smith and L. M. Atkins. E. R. Stine, C.-A. M. A. Mendonca-Dias, E. Gaggelli and P. Lauterbur. M. A. Basinger, R. L. Forti, L. T. Burka, M. M. Jones, W. M. Mitchell, J. E. Johnson and S. J. Gibbs. 1. Unable to display preview. P. W. Durbin, D. L. White, N. Jeung, F. L. Weitle, L. C. Uhlir, E. C. Jones, F. W. Breunger and K. N. Raymond. J. P. Lavender, J. Lowe and J. R. Barker. R. B. Lauffer, W. L. Greif, D. D. Stark, A. C. Vincent, S. Saini, V. Wedeen and T. J. Brady. B. Porter, K. P. Hoyes, R. Abeysinghe, E. R. Huehns and R. D. Hider. K. E. Linder, M. F. Malley, J. A. Davison, A. G. Jones, C. Orvig and M. Sohn. S. Vallabhajosula, R. E. Zimmerman and M. Picard. This chapter is distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Metal ions are often used for diagnostic medical imaging. M. R. Raichle, J. O. Eichung and M. G. Straatman. Y. Coverage of other precious metals includes gold, ruthenium (currently two complexes in clinical anticancer trials), palladium (much more kinetically labile than platinum, currently the subject of research) and rhodium (anticancer potential). Silver, J. H. V. Aposhian, C. H. Tadlock and T. E. Moon. Application of platina complexes in the treatment of tumor]. Liang and Y.-Y. H. L. Maxon, S. R. Thomas, V. S. Hertzberg, L. E. Schroder, E. A. Deutsch, K. F. Libson, R. C. Samaratunga, C. C. Williams and J. S. Moulton. In addition, compounds of radioactive metal ions such as 99mTc and complexes of paramagnetic metals such as Gd(III) are now in wide spread use as imaging agents for the diagnosis of disease. pp 149-197 | M. Misra, M. Athar, S. K. Hasan and R. C. Srinivastava. D. P. Nowotnik, L. R. Canning and S. A. Cumming. It is noteworthy to mention that in vivo these ligands will compete for a particular metal ion with a variety of other ligands determining that the extrapolation of this in vitro behavior should be done with moderation. We share our knowledge and peer-reveiwed research papers with libraries, scientific and engineering societies, and also work with corporate R&D departments and government entities. Transition metal complexes with low lying excited states are finding increasing use as photosensitizers. This service is more advanced with JavaScript available, Metal Complexes in Aqueous Solutions Role and application of vanadium, silicon, gold, cobalt, arsen and bismuth. Other techniques such as elemental analysis, electrochemical, and thermal methods were also employed for the assessment of the complexation ratio. Liang, X-H. Xu, X.-M. Yan and J.-S. Zhang. Both of these factors are important in biological systems because of the fact that all metal ions are subject to interaction with the natural ligands that are present in body fluids for the purpose of storage, transport and the regulation of the activity of natural metal ions that are needed for various metabolic purposes. R. Grady, 5th International Conference on Iron Chelation in the Treatment of Thalassemia and Other Diseases, No. M. W. Brechbiel, T. J. McMurry and O. G. R. Gale, L. M. Atkins, E. M. Walker Jr., A. S. V. Deshpande, S. J. Denardo, C. F. Meares, M. J. McCall, G. P. Adams and G. L. Genardo. © 2020 Springer Nature Switzerland AG. Z.-Q. The success of the clinical uses of cisplatin, cis - [Pt II (NH 3) 2 Cl 2 ], has stimulated considerable interest in using other metal complexes as new therapeutic agents. Metals of main group of elements. 2H2O, and [Cu(TBA)2][Hg(SCN)4].H2O and then were characterized by elemental analysis, FTIR spectroscopy, electron paramagnetic resonance (EPR) spectroscopy, and thermal methods establishing the combination ratio Cu:TBA 1:2, the presence of water of crystallization, and the coordination system. Chapter 18 by N. Farrell, deals with the use of metal … Metals in Medicine Metal containing drugs are important for a few medical applications including diagnosis and treatment. Mathias, Y. These keywords were added by machine and not by the authors. K. E. Linder, A. Davison, J. C. Dewan, C. E, Costello and S. Maleknia. Sun, C. J. Anderson, T. S. Pajeau, D. E. Reichert, R. D. Hancock, R. J. Motekaitis, A. E. Martell, and M. J. Welch. The EPR spectra showed that the Cu2+ ions were disposed in an octahedral vicinity of axial symmetry with a different hyperfine structure of the three complexes [25–27]. M. G. Cherian, S. Onosaka, G. K. Carson and P. A. W. Dean. Sun, C.J. properties of transition metal complexes [7]. The study of the complexes structure and of their biological importance represented the major research interest toward the use of organic drugs as ligands in coordination chemistry for their application in the biomedical field. Figure 25.6. When a ligand is designed to remove a certain metal ion because it has reached toxic levels, it must be as selective as possible for that metal ion so as not to disturb the metals that are naturally present. M. E. Lund, T. W. Clarkson and M. Berlin, M. L. Thakur, M. W. Merrick and W. E. Ganasekera, In. Cyanide complexes also find application in electroplating. ), bioavailability, membrane permeability, toxicity, and rapid elimination of the ligand and its metal chelate without spreading the undesired metal to other organs throughout the body. These include (1) the selective precipitation of metal ions as complexes—for example, nickel(2+) ion as the dimethylglyoxime complex … II. Such factors include the method of administration (oral, sub-cutaneous, intravenous injection, etc. Metals Application A. It will be the philosophy of this chapter that the thermodynamic stability of a metal chelate should be maximized, and the principles described in this book will be used for this purpose. 2. Xu, Y.-Z. [Application of metal ions and their complexes in medicine II. D. D. Dischino, M. J. Welch and M. R. Kilbourn. Tao, Y.-Y. Let us now study the uses of these unique elements in some more detail. Metals in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. B. Porter and E. R. Huehns. Z. Zhang, C. A. Chang, H. G. Brittain, C. M. Garrison, J. Tesler and M. F. Tweedle. S. A. Zuckman, G. M. Freeman, D. E. Groutner. J. H. Graziano, D. Cuccia and E. Friedheim. M. Piscator, In: Cadmium, E. C. Foulkes, Ed., Springer-Verlag, Berlin, 1986, p.179. Z. Gougouts, S. E. Unger and A. D. Nunn. M. W. Brechbiel, O. Edited by a team of highly respected researchers combining their expertise in chemistry, physics, and medicine, this book focuses on the use of rutheniumcontaining complexes in artificial photosynthesis and medicine. Hsu, T. D. Hoover, H. V. Aposhian and D. E. Carter. R. J. Motekaitis, A. E. Martell, and M. J. Welch. Green. The application of inorganic chemistry to medicine (“Elemental Medicine”) is a rapidly developing field, and novel therapeutic and diagnostic metal complexes are now having an impact on medical practice. Metal ions are of great importance not only in the vital functions of living organisms, but also they can be intensively used in analysis and control methods for pharmaceutical substances by forming complexes that can be detected by using different physicochemical methods such as spectroscopy, chromatography, microscopy, etc. E. R. Huehns, J. Chen, J.-S. Zhang, Y.-Y. W. H. Bakker, R. Albert, C. Bruns, W. A. P. Breeman, L. J. Hofland, P. Marbach, J. Pless, D. Pralet, B. Stolz, J. W. Roper, S. W. J. Lamberts, T. J. Biscer and E. P. Krenning. C. J. Mathias, M. J. Welch, M. R. Raichle, M. A. Mintun, L. L. Lick, A. H. McGuire, K. R. Zinn, E. K. John and M. A. Application of Transition Metals: The application of transition metals is as follows: 1. Partially Filled D Shell: For transition metals, the variable number of electrons in the d shell or f shell (for lanthanides) influences the electronic and magnetic properties of transition metal complexes [7]. We are IntechOpen, the world's leading publisher of Open Access books. J. This process is experimental and the keywords may be updated as the learning algorithm improves. The vast majority of investigated compounds in modern medicine are based on organic molecules. T. P. Coogan, D. M. Latta, E. T. Snow and M. Costa. 165–187. Z. Gougoutas, M. F. Tweedle, D. W. Lee and L. J. Wilson. 2 b: Ligands used in biological systems. K. N. Raymond, V. L. Pecoraro and F. L. Weitl, In: Development of Iron Chelators for Clinical Use, A. E. Martell, W. F. Anderson and D. G. Badman, Eds., Elsevier/North Holland, New York, 1981, pp. Brown, K. N. Ham, J. K. Dawborn and J. M. Xipell. Many studies were conducted concerning the synthesis and the investigation of metal complexes in which the pharmaceutical substances play the role of ligand highlighting their increasing clinical and commercial importance. R. C. Hider, S. Singh, J. S. Jurisson, E. O. Schlemper, D. E. Troutner, L. R. Canning, D. P. Nowotnik and R. D. Neirinckx. Major work horses are those derived from polypyridine complexes and metalloporphyrins. C. A. Burnham, S. Aronow and D. L. Brownell. Sun, R. J. Motekaitis, A. E. Martell and M. J. Welch. D. J. Weatherall, In: Development of Iron Chelators for Clinical Use, A. E. Martell, W. F. Anderson and D. G. Badman, Eds., Elsevier/North Holland, New York, 1981, pp. E. N. Treher, L. C. Francesconi, J. Metal Complexes of Pharmaceutical Substances, Spectroscopic Analyses - Developments and Applications, Eram Sharmin and Fahmina Zafar, IntechOpen, DOI: 10.5772/65390. S. R. Cooper, Paper No. M. J. Sundberg, C. F. Meares and D. A. Goodwin. R. D. Hancock and A. E. Martell, A. E. J. Chem. C. A. Chang, L. C. Francesconi, M. F. Malley, K. Kumar, J. The scanning electron microscopy images revealed the morphology of the metal complexes underlying their crystalline or amorphous character. Transition metals are extremely versatile elements, which show potential for application in various fields such as medicine, construction, energy, etc., due to their properties of malleability and ductility. R. M. Pearlstein, W. M. Davis, A. G. Jones and A. Davison. We know that transition metals have this special property of forming coordination complexes. Within the last decades, the field of medicinial chemistry is shifting towards the application of metal complexes. Sun, R. J. Motekaitis and A. E. Martell. P. L. Carney, P. E.; Rogers and K. D. Johnson. Many metal-ligand complexes have characteristic colors and are useful for visual identification of certain metal ions in solution, such as: [Co(H 2 6 ] 2+ is a vibrant pink. Their interesting optical, magnetic, radioactive, and other properties enable their use in many non-invasive and quick methods: e.g., optical imaging, magnetic resonance imaging (MRI), and positron emission tomography (PET). This is because of the chemistry that involves these compounds. Transition metals are applied in the organic reactions. A. Koutcher, C. T. Burt, R. B. Lauffer and T. J. Brady. The most fundamental is the simple coordination and dissociation of ligands. Not affiliated Previous chapters have emphasized the factors involved in designing metal complexes with maximum stability, and with a large degree of selectivity. T. H. Tulip, J. Calabrese, J. F. Kronange, A. Davison and A. G. Jones, In: W. A. Volkert, D. E. Troutner and R. A. Holmes. White, E. C. Ramos, T. R. Johnson, H. A. Macapinlac and M. E. Moseley. S. I. Kang, R. S. Ranganathan, J. E. Emswiler, K. Kumar, J. Mathias, M. J. Welch, W. L. Madsen and A. E. Martell. B. Porter and R. C. Hider. P. K. Singh, S. G. Jones, G. R. Gale, M. M. Jones, A. It should always be taken into consideration that the therapeutic effect will be mainly influenced by the conformation of the drug ligands molecules and by their ability to combine with receptors. S. Jurisson, E. A. Schlemper, D. E. Troutner, L. R. Canning, L. R. D. P. Nowotnik and R. D. Neirinckx, In: U. Mazzi, E. Roncair, G. Bandoli and L. Magon. Coordination compounds offer many binding modes to polynucleotides, includ-ing outer-sphere noncovalent binding, metal coordination to nucleobase and phosphate backbone 810 Metal Complexes as Drugs and Chemotherapeutic Agents were found with potential anticancer activities. A. Ortega, J. L. Domingo, M. Gomez and J. Corbella. Our readership spans scientists, professors, researchers, librarians, and students, as well as business professionals. Thus, the use of these metal complexes in the biomedical field can be realized by various purposes such as the introduction in the body of deficient metal ions, the use of the ligands as antidotes in various intoxications with metals, and the acquirement of pharmacotherapy effects by blocking metal ions essential for some enzymatic systems. S. Jurisson, D. Berning, W. Jia and D. Ma. More than 140 copper complexes of non-steroidal anti-inflammatory agents (aspirin and ibuprofen, for example) have been shown to be more active than their parent compounds. Non-platinum complexes (like Fe, Pd, Ru, Cu, Bi, Zn, etc.) The molecules of the pharmaceutical substances have one or more unshared electron pairs that can function as ligands. Y. C. F. Meares, D. A. Goodwin and C. S. H. Leung. Many patients admit ted overnight to a hospital in the U.S. will receive an injection of a 99mTc compound for radiodiagnostic purposes. J. Login to your personal dashboard for more detailed statistics on your publications. Various chemical, optical, and magnetic properties of the metal complexes of some pharmaceutical substances (pyrazinamide, nicotinamide, nicotinic acid, tolbutamide, theophylline, captopril, clonidine, and guanfacine) have been studied by using a wide range of techniques. C. J. Mathias, Y. Sun. Not logged in B. L. Engelstad, D. I. D. Brenner, A. Davison, J. Lister-Jones and A. G. Jones. Y. J. Li, A. E. Martell, R. D. Hancock, J. H. Reibenspies, C. J. Anderson, and M. J. Welch, in press. P. W. Durbin, N. Jueng, E. S. Jones, F. L. Weitl and K. N. Raymond. For this reason, efforts have been made to search for novel solutions. M. Rubin, S. Gignac, S. P. Bessman and E. L. Belknap. Hider and J. Porter. B. Porter, S. Hirani, M. Streater, R. C. Hider, and E. R. Huehns. Hoyes, R. C. Hider, G. W. Philpott, M. J. McCall, G. P. and. Meeting, Washington, D.C., August 20–25, 1994 P. Bessman and R.! J. Baldas, J. 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